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PTPRN2 protein tyrosine phosphatase receptor type N2 [ Homo sapiens (human) ]

Gene ID: 5799, updated on 17-Jun-2024

Summary

Official Symbol
PTPRN2provided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type N2provided by HGNC
Primary source
HGNC:HGNC:9677
See related
Ensembl:ENSG00000155093 MIM:601698; AllianceGenome:HGNC:9677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
Summary
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Broad expression in brain (RPKM 7.2), stomach (RPKM 4.9) and 18 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See PTPRN2 in Genome Data Viewer
Location:
7q36.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (157539056..158587823, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (158727687..159797184, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (157331750..158380515, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927914 Neighboring gene Sharpr-MPRA regulatory region 4962 Neighboring gene MPRA-validated peak6872 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26930 Neighboring gene uncharacterized LOC105375610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157305630-157306130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157306131-157306631 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157307834-157308764 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97964 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157313607-157314110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157314111-157314614 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:157355168-157356367 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:157357033-157358232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157388362-157388862 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:157387093-157388292 Neighboring gene uncharacterized LOC105375615 Neighboring gene uncharacterized LOC105375614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157410237-157410746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157414918-157415418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157415419-157415919 Neighboring gene microRNA 153-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157453869-157454368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157461523-157462416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157462417-157463309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157468593-157469378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157469379-157470162 Neighboring gene MPRA-validated peak6875 silencer Neighboring gene OCT4 hESC enhancer GRCh37_chr7:157525094-157525825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:157588757-157589258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157586225-157586786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157589794-157590294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157607483-157607984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157619124-157619632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157621801-157622674 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:157637302-157638501 Neighboring gene MPRA-validated peak6876 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157666565-157667400 Neighboring gene PTPRN2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157679661-157680178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157689624-157690124 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_97987 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:157725255-157726454 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:157748173-157748781 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:157763321-157763527 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157775009-157775954 Neighboring gene uncharacterized LOC105375613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157782013-157782612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157783213-157783812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157783813-157784412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157791993-157792738 Neighboring gene NANOG hESC enhancer GRCh37_chr7:157792768-157793272 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157799559-157800539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157800540-157801519 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157802753-157803315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157808367-157809026 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157809027-157809686 Neighboring gene Sharpr-MPRA regulatory region 9999 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:157843588-157843764 Neighboring gene MPRA-validated peak6878 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157859561-157860514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157870087-157870586 Neighboring gene Sharpr-MPRA regulatory region 5343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157903511-157904242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157904657-157905158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157926052-157926594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157929890-157930772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157935377-157936298 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr7:157940629-157941180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:157941181-157941730 Neighboring gene D7S22 minisatellite repeat instability region Neighboring gene ReSE screen-validated silencer GRCh37_chr7:157954594-157954842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:157957089-157957613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:157987247-157987747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158030483-158031396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158037992-158038492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158053060-158053970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158069190-158069934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158073864-158074606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158075350-158076092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158103424-158103936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158108910-158109661 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158109662-158110412 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158110413-158111164 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158118125-158119111 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:158122041-158122238 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:158127303-158127803 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:158134077-158134576 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:158134599-158135798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158142965-158143559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158144749-158145341 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:158166900-158168099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158190023-158190630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158206830-158207354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158207355-158207879 Neighboring gene MPRA-validated peak6880 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:158230280-158230780 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:158261913-158262077 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158289893-158290448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158292995-158293940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158300949-158301460 Neighboring gene Sharpr-MPRA regulatory region 11620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158319662-158320162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158320163-158320663 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158322953-158323722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158323723-158324491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158330775-158331759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:158342742-158343550 Neighboring gene MPRA-validated peak6883 silencer Neighboring gene uncharacterized LOC124901793 Neighboring gene Sharpr-MPRA regulatory region 10119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:158389617-158390116 Neighboring gene microRNA 595 Neighboring gene long intergenic non-protein coding RNA 1022 Neighboring gene microRNA 5707 Neighboring gene THAP domain containing 5 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
EBI GWAS Catalog
Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.
EBI GWAS Catalog
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in insulin secretion involved in cellular response to glucose stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase N2
Names
IAR/receptor-like protein-tyrosine phosphatase
islet cell autoantigen-related protein
phogrin
protein tyrosine phosphatase receptor pi
protein tyrosine phosphatase, receptor type, N polypeptide 2
tyrosine phosphatase IA-2 beta
NP_001295196.1
NP_001295197.1
NP_002838.2
NP_570857.2
NP_570858.2
XP_011514748.1
XP_011514749.1
XP_011514750.1
XP_011514751.1
XP_016867964.1
XP_016867965.1
XP_047276634.1
XP_047276635.1
XP_047276636.1
XP_054214712.1
XP_054214713.1
XP_054214714.1
XP_054214715.1
XP_054214716.1
XP_054214717.1
XP_054214718.1
XP_054214719.1
XP_054214720.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029966.2 RefSeqGene

    Range
    5000..1053767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308267.2NP_001295196.1  receptor-type tyrosine-protein phosphatase N2 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AC005481, AC006372, AC011899, AC078942, AC093662, AC093856
    Consensus CDS
    CCDS78294.1
    UniProtKB/TrEMBL
    E7EM83, Q9Y4I9
    Related
    ENSP00000387114.1, ENST00000409483.5
    Conserved Domains (4) summary
    smart00194
    Location:707966
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:734966
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:474559
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:55100
    RESP18; RESP18 domain
  2. NM_001308268.2NP_001295197.1  receptor-type tyrosine-protein phosphatase N2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC005481, AC006372, AC011899, AC019043, AC078942, AC093856
    UniProtKB/TrEMBL
    Q9Y4I9
    Conserved Domains (4) summary
    smart00194
    Location:7681027
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:7951027
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:535620
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:82161
    RESP18; RESP18 domain
  3. NM_002847.5NP_002838.2  receptor-type tyrosine-protein phosphatase N2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_002838.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC005481, AC006372, AC011899, AC019043, AC078942, AC093662, AC093856
    Consensus CDS
    CCDS5947.1
    UniProtKB/Swiss-Prot
    E9PC57, Q8N4I5, Q92662, Q92932, Q9Y4F8, Q9Y4I6
    UniProtKB/TrEMBL
    Q9Y4I9
    Related
    ENSP00000374069.4, ENST00000389418.9
    Conserved Domains (4) summary
    smart00194
    Location:7451004
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:7721004
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:512597
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:59138
    RESP18; RESP18 domain
  4. NM_130842.4NP_570857.2  receptor-type tyrosine-protein phosphatase N2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC005481, AC006372, AC011899, AC019043, AC093662, AC093856
    Consensus CDS
    CCDS5948.1
    UniProtKB/TrEMBL
    Q9Y4I9
    Related
    ENSP00000374067.4, ENST00000389416.8
    Conserved Domains (4) summary
    smart00194
    Location:728987
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:755987
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:495580
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:42121
    RESP18; RESP18 domain
  5. NM_130843.4NP_570858.2  receptor-type tyrosine-protein phosphatase N2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC005481, AC006372, AC011899, AC019043, AC078942, AC093662, AC093856
    Consensus CDS
    CCDS5949.1
    UniProtKB/TrEMBL
    Q9Y4I9
    Related
    ENSP00000374064.3, ENST00000389413.7
    Conserved Domains (4) summary
    smart00194
    Location:716975
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:743975
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam11548
    Location:516568
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:59138
    RESP18; RESP18 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    157539056..158587823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420678.1XP_047276634.1  receptor-type tyrosine-protein phosphatase N2 isoform X1

    UniProtKB/TrEMBL
    Q9Y4I9
  2. XM_047420679.1XP_047276635.1  receptor-type tyrosine-protein phosphatase N2 isoform X3

    UniProtKB/TrEMBL
    Q9Y4I9
  3. XM_017012475.1XP_016867964.1  receptor-type tyrosine-protein phosphatase N2 isoform X2

    UniProtKB/TrEMBL
    Q9Y4I9
  4. XM_011516446.2XP_011514748.1  receptor-type tyrosine-protein phosphatase N2 isoform X5

    UniProtKB/TrEMBL
    Q9Y4I9
    Conserved Domains (3) summary
    pfam11548
    Location:512597
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:59138
    RESP18; RESP18 domain
    cl21483
    Location:772832
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. XM_017012476.2XP_016867965.1  receptor-type tyrosine-protein phosphatase N2 isoform X4

    UniProtKB/TrEMBL
    Q9Y4I9
  6. XM_011516447.3XP_011514749.1  receptor-type tyrosine-protein phosphatase N2 isoform X6

    Conserved Domains (2) summary
    pfam11548
    Location:512575
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:59138
    RESP18; RESP18 domain
  7. XM_047420680.1XP_047276636.1  receptor-type tyrosine-protein phosphatase N2 isoform X8

  8. XM_011516448.4XP_011514750.1  receptor-type tyrosine-protein phosphatase N2 isoform X7

    UniProtKB/TrEMBL
    I6L9F8
    Conserved Domains (2) summary
    pfam11548
    Location:512575
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:59138
    RESP18; RESP18 domain
  9. XM_011516449.3XP_011514751.1  receptor-type tyrosine-protein phosphatase N2 isoform X9

    UniProtKB/TrEMBL
    I6L9F8
    Conserved Domains (2) summary
    pfam11548
    Location:512563
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:59138
    RESP18; RESP18 domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    158727687..159797184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358737.1XP_054214712.1  receptor-type tyrosine-protein phosphatase N2 isoform X1

    UniProtKB/TrEMBL
    Q9Y4I9
  2. XM_054358739.1XP_054214714.1  receptor-type tyrosine-protein phosphatase N2 isoform X3

    UniProtKB/TrEMBL
    Q9Y4I9
  3. XM_054358738.1XP_054214713.1  receptor-type tyrosine-protein phosphatase N2 isoform X2

    UniProtKB/TrEMBL
    Q9Y4I9
  4. XM_054358741.1XP_054214716.1  receptor-type tyrosine-protein phosphatase N2 isoform X5

    UniProtKB/TrEMBL
    Q9Y4I9
  5. XM_054358740.1XP_054214715.1  receptor-type tyrosine-protein phosphatase N2 isoform X4

    UniProtKB/TrEMBL
    Q9Y4I9
  6. XM_054358742.1XP_054214717.1  receptor-type tyrosine-protein phosphatase N2 isoform X6

  7. XM_054358744.1XP_054214719.1  receptor-type tyrosine-protein phosphatase N2 isoform X8

  8. XM_054358743.1XP_054214718.1  receptor-type tyrosine-protein phosphatase N2 isoform X7

    UniProtKB/TrEMBL
    I6L9F8
  9. XM_054358745.1XP_054214720.1  receptor-type tyrosine-protein phosphatase N2 isoform X9

    UniProtKB/TrEMBL
    I6L9F8