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PTPRK protein tyrosine phosphatase, receptor type K [ Homo sapiens (human) ]

Gene ID: 5796, updated on 7-Oct-2018

Summary

Official Symbol
PTPRKprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Kprovided by HGNC
Primary source
HGNC:HGNC:9674
See related
Ensembl:ENSG00000152894 MIM:602545; Vega:OTTHUMG00000015536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R-PTP-kappa
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 16.8), colon (RPKM 13.7) and 24 other tissues See more
Orthologs

Genomic context

See PTPRK in Genome Data Viewer
Location:
6q22.33
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (127968779..128520674, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (128289924..128841870, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267973 Neighboring gene thymocyte selection associated Neighboring gene mitochondrial ribosomal protein S17 pseudogene 5 Neighboring gene uncharacterized LOC101928140 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 5 Neighboring gene ribosomal protein L21 pseudogene 64

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study for age-related hearing impairment in the Saami.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRK PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes
  • EGFR downregulation, organism-specific biosystem (from REACTOME)
    EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
    Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686C2268, DKFZp779N1045

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
gamma-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
adherens junction IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
leading edge membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase kappa
Names
dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa
protein-tyrosine phosphatase kappa
protein-tyrosine phosphatase, receptor type, kappa
NP_001129120.1
NP_001278910.1
NP_001278911.1
NP_001278912.1
NP_001278913.1
NP_002835.2
XP_006715600.1
XP_011534316.1
XP_011534317.1
XP_011534318.1
XP_011534319.1
XP_011534320.1
XP_011534322.1
XP_011534323.1
XP_016866634.1
XP_016866635.1
XP_016866636.1
XP_016866637.1
XP_016866638.1
XP_016866639.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135648.2NP_001129120.1  receptor-type tyrosine-protein phosphatase kappa isoform a precursor

    See identical proteins and their annotated locations for NP_001129120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks three alternate in-frame exons compared to variant 3. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AL590006, BC144512, BQ018138, DB020920
    Consensus CDS
    CCDS47473.1
    UniProtKB/Swiss-Prot
    Q15262
    Related
    ENSP00000357196.5, OTTHUMP00000233054, ENST00000368213.9, OTTHUMT00000390044
    Conserved Domains (4) summary
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9141147
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:488583
    fn3; Fibronectin type III domain
  2. NM_001291981.1NP_001278910.1  receptor-type tyrosine-protein phosphatase kappa isoform c precursor

    See identical proteins and their annotated locations for NP_001278910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    BC144512, BC144513, BQ018138, DB020920
    Consensus CDS
    CCDS78179.1
    UniProtKB/Swiss-Prot
    Q15262
    Related
    ENSP00000432973.1, OTTHUMP00000233080, ENST00000532331.5, OTTHUMT00000390081
    Conserved Domains (4) summary
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9301163
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:488583
    fn3; Fibronectin type III domain
  3. NM_001291982.1NP_001278911.1  receptor-type tyrosine-protein phosphatase kappa isoform d precursor

    See identical proteins and their annotated locations for NP_001278911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform c.
    Source sequence(s)
    AK295028, DB020920
    UniProtKB/TrEMBL
    B4DHC3
    Conserved Domains (6) summary
    cd06263
    Location:36192
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00063
    Location:488589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294372
    fn3; Fibronectin type III domain
    cl11960
    Location:204284
    Ig; Immunoglobulin domain
  4. NM_001291983.1NP_001278912.1  receptor-type tyrosine-protein phosphatase kappa isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding sequence compared to variant 3. The resulting isoform (d) has shorter and distinct N- and C-termini compared to isoform c.
    Source sequence(s)
    AB209670, AK295028, AL590006, DB020920
    UniProtKB/TrEMBL
    B4DHC3, Q59EZ1
    Conserved Domains (5) summary
    cd06263
    Location:3663
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00410
    Location:73159
    IG_like; Immunoglobulin like
    cd00063
    Location:359460
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:165243
    fn3; Fibronectin type III domain
    cl11960
    Location:75155
    Ig; Immunoglobulin domain
  5. NM_001291984.1NP_001278913.1  receptor-type tyrosine-protein phosphatase kappa isoform f precursor

    See identical proteins and their annotated locations for NP_001278913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three alternate in-frame exons and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AL357621, AL590006, BC144513, BQ018138, DB020920, Z70660
    Consensus CDS
    CCDS75517.1
    UniProtKB/Swiss-Prot
    Q15262
    Related
    ENSP00000357198.3, OTTHUMP00000017182, ENST00000368215.7, OTTHUMT00000042163
    Conserved Domains (4) summary
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9131140
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:488583
    fn3; Fibronectin type III domain
  6. NM_002844.3NP_002835.2  receptor-type tyrosine-protein phosphatase kappa isoform b precursor

    See identical proteins and their annotated locations for NP_002835.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform c.
    Source sequence(s)
    AF533875, AK295028, BC140775, BQ018138, DA790525
    Consensus CDS
    CCDS5137.1
    UniProtKB/Swiss-Prot
    Q15262
    UniProtKB/TrEMBL
    B4DHC3, Q86WJ2
    Related
    ENSP00000357209.4, OTTHUMP00000017180, ENST00000368226.8, OTTHUMT00000042161
    Conserved Domains (4) summary
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9141141
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:488583
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    127968779..128520674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715537.3XP_006715600.1  receptor-type tyrosine-protein phosphatase kappa isoform X4

    See identical proteins and their annotated locations for XP_006715600.1

    Conserved Domains (9) summary
    cd06263
    Location:36192
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8861146
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9131146
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:488589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294372
    fn3; Fibronectin type III domain
    pfam00102
    Location:12061440
    Y_phosphatase; Protein-tyrosine phosphatase
    cl11960
    Location:204284
    Ig; Immunoglobulin domain
  2. XM_011536014.3XP_011534316.1  receptor-type tyrosine-protein phosphatase kappa isoform X1

    See identical proteins and their annotated locations for XP_011534316.1

    Conserved Domains (9) summary
    cd06263
    Location:36192
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9021162
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9291162
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:488589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294372
    fn3; Fibronectin type III domain
    pfam00102
    Location:12221456
    Y_phosphatase; Protein-tyrosine phosphatase
    cl11960
    Location:204284
    Ig; Immunoglobulin domain
  3. XM_011536015.3XP_011534317.1  receptor-type tyrosine-protein phosphatase kappa isoform X2

    See identical proteins and their annotated locations for XP_011534317.1

    UniProtKB/TrEMBL
    Q5TG12
    Related
    ENSP00000357193.3, OTTHUMP00000017181, ENST00000368210.7
    Conserved Domains (4) summary
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9261159
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:488583
    fn3; Fibronectin type III domain
  4. XM_011536016.3XP_011534318.1  receptor-type tyrosine-protein phosphatase kappa isoform X3

    See identical proteins and their annotated locations for XP_011534318.1

    Conserved Domains (9) summary
    cd06263
    Location:36192
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9031157
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00047
    Location:9301157
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:488589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294372
    fn3; Fibronectin type III domain
    pfam00102
    Location:12171451
    Y_phosphatase; Protein-tyrosine phosphatase
    cl11960
    Location:204284
    Ig; Immunoglobulin domain
  5. XM_017011146.1XP_016866635.1  receptor-type tyrosine-protein phosphatase kappa isoform X6

  6. XM_011536018.2XP_011534320.1  receptor-type tyrosine-protein phosphatase kappa isoform X5

    See identical proteins and their annotated locations for XP_011534320.1

    Conserved Domains (4) summary
    smart00137
    Location:1121
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:131217
    IG_like; Immunoglobulin like
    cd00047
    Location:8591092
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:417512
    fn3; Fibronectin type III domain
  7. XM_017011147.1XP_016866636.1  receptor-type tyrosine-protein phosphatase kappa isoform X7

  8. XM_017011148.1XP_016866637.1  receptor-type tyrosine-protein phosphatase kappa isoform X8

  9. XM_017011145.1XP_016866634.1  receptor-type tyrosine-protein phosphatase kappa isoform X6

  10. XM_011536017.3XP_011534319.1  receptor-type tyrosine-protein phosphatase kappa isoform X5

    See identical proteins and their annotated locations for XP_011534319.1

    Conserved Domains (4) summary
    smart00137
    Location:1121
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:131217
    IG_like; Immunoglobulin like
    cd00047
    Location:8591092
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00041
    Location:417512
    fn3; Fibronectin type III domain
  11. XM_017011149.2XP_016866638.1  receptor-type tyrosine-protein phosphatase kappa isoform X11

  12. XM_017011150.2XP_016866639.1  receptor-type tyrosine-protein phosphatase kappa isoform X12

  13. XM_011536020.3XP_011534322.1  receptor-type tyrosine-protein phosphatase kappa isoform X9

    See identical proteins and their annotated locations for XP_011534322.1

    Conserved Domains (6) summary
    cd06263
    Location:36192
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00063
    Location:488589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294372
    fn3; Fibronectin type III domain
    cl11960
    Location:204284
    Ig; Immunoglobulin domain
  14. XM_011536021.3XP_011534323.1  receptor-type tyrosine-protein phosphatase kappa isoform X10

    See identical proteins and their annotated locations for XP_011534323.1

    Conserved Domains (6) summary
    cd06263
    Location:36192
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:32192
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:202288
    IG_like; Immunoglobulin like
    cd00063
    Location:488589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:294372
    fn3; Fibronectin type III domain
    cl11960
    Location:204284
    Ig; Immunoglobulin domain

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187556.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    313977..870008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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