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PTPRF protein tyrosine phosphatase, receptor type F [ Homo sapiens (human) ]

Gene ID: 5792, updated on 7-Oct-2018

Summary

Official Symbol
PTPRFprovided by HGNC
Official Full Name
protein tyrosine phosphatase, receptor type Fprovided by HGNC
Primary source
HGNC:HGNC:9670
See related
Ensembl:ENSG00000142949 MIM:179590; Vega:OTTHUMG00000007501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAR; BNAH2
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 56.2), skin (RPKM 52.7) and 21 other tissues See more
Orthologs

Genomic context

See PTPRF in Genome Data Viewer
Location:
1p34.2
Exon count:
43
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (43522238..43623672)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43991708..44089343)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SZT2, KICSTOR complex subunit Neighboring gene SZT2 antisense RNA 1 Neighboring gene microRNA 6735 Neighboring gene hydroxypyruvate isomerase (putative) Neighboring gene lysine demethylase 4A Neighboring gene uncharacterized LOC101929592 Neighboring gene KDM4A antisense RNA 1 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Breasts and/or nipples, aplasia or hypoplasia of, 2
MedGen: C4014918 OMIM: 616001 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
NHGRI GWA Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRF PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adherens junction, organism-specific biosystem (from KEGG)
    Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Adherens junction, conserved biosystem (from KEGG)
    Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Insulin resistance, organism-specific biosystem (from KEGG)
    Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
  • SALM protein interactions at the synapses, organism-specific biosystem (from REACTOME)
    SALM protein interactions at the synapses, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43335, FLJ45062, FLJ45567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
chondroitin sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
 
synaptic membrane adhesion EXP
Inferred from Experiment
more info
PubMed 
synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase F
Names
LCA-homolog
leukocyte antigen-related (LAR) PTP receptor
leukocyte antigen-related tyrosine phosphatase
leukocyte common antigen related
protein tyrosine phosphatase, receptor type, F polypeptide
receptor-linked protein-tyrosine phosphatase LAR
NP_001316066.1
NP_001316067.1
NP_001316068.1
NP_001316069.1
NP_002831.2
NP_569707.2
XP_005271136.1
XP_005271137.1
XP_005271138.1
XP_005271139.1
XP_006710858.1
XP_006710859.1
XP_006710860.1
XP_006710861.1
XP_006710862.1
XP_006710863.1
XP_006710864.1
XP_011540173.1
XP_011540174.1
XP_011540175.1
XP_016857431.1
XP_016857432.1
XP_016857433.1
XP_016857434.1
XP_016857435.1
XP_016857438.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047072.1 RefSeqGene

    Range
    13623..106435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329137.1NP_001316066.1  receptor-type tyrosine-protein phosphatase F isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC092815, AL583862, BU624266, DA339772
  2. NM_001329138.1NP_001316067.1  receptor-type tyrosine-protein phosphatase F isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC092815, AL583862, BU624266, DA339772
  3. NM_001329139.1NP_001316068.1  receptor-type tyrosine-protein phosphatase F isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC092815, AL583862, BU624266
  4. NM_001329140.1NP_001316069.1  receptor-type tyrosine-protein phosphatase F isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AB621807, AC092815, AL583862, BU624266
    UniProtKB/TrEMBL
    G1UI20
  5. NM_002840.4NP_002831.2  receptor-type tyrosine-protein phosphatase F isoform 1 precursor

    See identical proteins and their annotated locations for NP_002831.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB621807, AC092815, BC048768, BU624266, Y00815
    Consensus CDS
    CCDS489.2
    UniProtKB/Swiss-Prot
    P10586
    UniProtKB/TrEMBL
    G1UI20
    Related
    ENSP00000353030.4, OTTHUMP00000008683, ENST00000359947.8, OTTHUMT00000019710
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13511606
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13771606
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain
  6. NM_130440.3NP_569707.2  receptor-type tyrosine-protein phosphatase F isoform 2 precursor

    See identical proteins and their annotated locations for NP_569707.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB621807, AC092815, BC048768, BU624266, Y00815
    Consensus CDS
    CCDS490.2
    UniProtKB/Swiss-Prot
    P10586
    UniProtKB/TrEMBL
    G1UI20
    Related
    ENSP00000398822.1, OTTHUMP00000008684, ENST00000438120.5, OTTHUMT00000019711
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13421597
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13681597
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    43522238..43623672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541873.2XP_011540175.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_011540175.1

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13661621
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13921621
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  2. XM_011541871.3XP_011540173.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_011540173.1

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13661621
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13921621
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  3. XM_011541872.3XP_011540174.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_011540174.1

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13661621
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13921621
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  4. XM_006710795.3XP_006710858.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_006710858.1

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13661621
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13921621
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  5. XM_017001949.1XP_016857438.1  receptor-type tyrosine-protein phosphatase F isoform X16

  6. XM_005271079.3XP_005271136.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_005271136.1

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13661621
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13921621
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  7. XM_006710798.3XP_006710861.1  receptor-type tyrosine-protein phosphatase F isoform X7

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13461601
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13721601
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  8. XM_017001944.1XP_016857433.1  receptor-type tyrosine-protein phosphatase F isoform X11

  9. XM_005271082.3XP_005271139.1  receptor-type tyrosine-protein phosphatase F isoform X13

    Conserved Domains (8) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12401495
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:12661495
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  10. XM_006710801.3XP_006710864.1  receptor-type tyrosine-protein phosphatase F isoform X14

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:11731428
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:11991428
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  11. XM_017001946.1XP_016857435.1  receptor-type tyrosine-protein phosphatase F isoform X15

  12. XM_006710797.3XP_006710860.1  receptor-type tyrosine-protein phosphatase F isoform X5

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13551610
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13811610
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  13. XM_006710796.3XP_006710859.1  receptor-type tyrosine-protein phosphatase F isoform X3

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13571612
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13831612
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  14. XM_006710799.3XP_006710862.1  receptor-type tyrosine-protein phosphatase F isoform X8

    Conserved Domains (8) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12641519
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:12901519
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  15. XM_006710800.3XP_006710863.1  receptor-type tyrosine-protein phosphatase F isoform X9

    Conserved Domains (8) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12551510
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:12811510
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  16. XM_005271080.3XP_005271137.1  receptor-type tyrosine-protein phosphatase F isoform X2

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13621617
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13881617
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain
  17. XM_005271081.3XP_005271138.1  receptor-type tyrosine-protein phosphatase F isoform X6

    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13531608
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13791608
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain
  18. XM_017001943.1XP_016857432.1  receptor-type tyrosine-protein phosphatase F isoform X10

  19. XM_017001945.1XP_016857434.1  receptor-type tyrosine-protein phosphatase F isoform X12

  20. XM_017001942.2XP_016857431.1  receptor-type tyrosine-protein phosphatase F isoform X4

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