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Cdc42se1 CDC42 small effector 1 [ Mus musculus (house mouse) ]

Gene ID: 57912, updated on 26-Sep-2022

Summary

Official Symbol
Cdc42se1provided by MGI
Official Full Name
CDC42 small effector 1provided by MGI
Primary source
MGI:MGI:1889510
See related
Ensembl:ENSMUSG00000046722 AllianceGenome:MGI:1889510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCIP1; Spec1; Cdcse1; 1300002M12Rik
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to act upstream of or within negative regulation of JNK cascade; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in cell cortex and cell junction. Predicted to be active in plasma membrane. Is expressed in cerebral cortex. Orthologous to human CDC42SE1 (CDC42 small effector 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 34.7), thymus adult (RPKM 34.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cdc42se1 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95135735..95143735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95228424..95236424)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene MINDY lysine 48 deubiquitinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within small GTPase mediated signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CDC42 small effector protein 1
Names
small protein effector 1 of Cdc42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038708.3NP_001033797.1  CDC42 small effector protein 1

    See identical proteins and their annotated locations for NP_001033797.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK004859, BC060964, CF105339, CJ290563
    Consensus CDS
    CCDS38545.1
    UniProtKB/Swiss-Prot
    Q8BHL7
    UniProtKB/TrEMBL
    A0A6P5PL80, A0A8C6GG47
    Related
    ENSMUSP00000102819.3, ENSMUST00000107201.9
    Conserved Domains (1) summary
    cl00113
    Location:2967
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
  2. NM_172395.3NP_765983.1  CDC42 small effector protein 1

    See identical proteins and their annotated locations for NP_765983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK004859, AV456394, CJ290563
    Consensus CDS
    CCDS38545.1
    UniProtKB/Swiss-Prot
    Q8BHL7
    UniProtKB/TrEMBL
    A0A6P5PL80, A0A8C6GG47
    Related
    ENSMUSP00000052986.6, ENSMUST00000053872.12
    Conserved Domains (1) summary
    cl00113
    Location:2967
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95135735..95143735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)