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PTPRE protein tyrosine phosphatase receptor type E [ Homo sapiens (human) ]

Gene ID: 5791, updated on 21-Dec-2019

Summary

Official Symbol
PTPREprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Eprovided by HGNC
Primary source
HGNC:HGNC:9669
See related
Ensembl:ENSG00000132334 MIM:600926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTPE; HPTPE; R-PTP-EPSILON
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015]
Expression
Broad expression in bone marrow (RPKM 31.9), appendix (RPKM 9.8) and 14 other tissues See more
Orthologs

Genomic context

See PTPRE in Genome Data Viewer
Location:
10q26.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (127907053..128085855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (129705325..129884180)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase pseudogene 1 Neighboring gene clarin 3 Neighboring gene lncRNA antisense to PTPRE protein-coding gene Neighboring gene marker of proliferation Ki-67 Neighboring gene long intergenic non-protein coding RNA 1163

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog
Genome-wide association with select biomarker traits in the Framingham Heart Study.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies PTPRE, a member of the protein tyrosine phosphatase family, is important for HIV-1 replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ57799, FLJ58245, DKFZp313F1310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase epsilon
Names
protein tyrosine phosphatase, receptor type, epsilon polypeptide
NP_001303605.1
NP_001303606.1
NP_001310283.1
NP_001310284.1
NP_001310285.1
NP_001310286.1
NP_006495.1
NP_569119.1
XP_005252748.1
XP_011538296.1
XP_011538297.1
XP_011538298.1
XP_011538300.1
XP_016871956.1
XP_016871957.1
XP_016871958.1
XP_024303860.1
XP_024303861.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029511.1 RefSeqGene

    Range
    5043..183795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316676.2NP_001303605.1  receptor-type tyrosine-protein phosphatase epsilon isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AF406557, AK026334, AL390236, BC031078, BC050062, BC071573, X54134
    UniProtKB/Swiss-Prot
    P23469
    UniProtKB/TrEMBL
    Q96P81
    Conserved Domains (2) summary
    smart00194
    Location:145404
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:172404
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001316677.2NP_001303606.1  receptor-type tyrosine-protein phosphatase epsilon isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon in place of the first 3 exons and lacks a large part of the 3' UTR compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. The encoded protein is a receptor type isoform of this PTP. Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AK026334, AK291828, BC071573
    Consensus CDS
    CCDS7657.1
    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:453688
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001323354.2NP_001310283.1  receptor-type tyrosine-protein phosphatase epsilon isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), along with variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AL390236
    Consensus CDS
    CCDS7657.1
    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:453688
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_001323355.2NP_001310284.1  receptor-type tyrosine-protein phosphatase epsilon isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL158166, AL390236
    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_001323356.2NP_001310285.1  receptor-type tyrosine-protein phosphatase epsilon isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL158166, AL390236
  6. NM_001323357.2NP_001310286.1  receptor-type tyrosine-protein phosphatase epsilon isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL390236
    Conserved Domains (2) summary
    smart00194
    Location:1173
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:233468
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. NM_006504.6NP_006495.1  receptor-type tyrosine-protein phosphatase epsilon isoform 1 precursor

    See identical proteins and their annotated locations for NP_006495.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks a 5' exon compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. The encoded protein is a receptor type isoform of this PTP. Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AF406557, AK026334, AL390236, BC031078, BC071573, X54134
    Consensus CDS
    CCDS7657.1
    UniProtKB/Swiss-Prot
    P23469
    UniProtKB/TrEMBL
    Q96P81
    Related
    ENSP00000254667.3, ENST00000254667.7
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:453688
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  8. NM_130435.5NP_569119.1  receptor-type tyrosine-protein phosphatase epsilon isoform 2

    See identical proteins and their annotated locations for NP_569119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in place of the first 5 exons compared to variant 3. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 3. The encoded protein is a cytoplasmic isoform of this PTP.
    Source sequence(s)
    AK026334, AK290414, AL390236, BC071573, DA470230
    Consensus CDS
    CCDS7658.1
    UniProtKB/Swiss-Prot
    P23469
    UniProtKB/TrEMBL
    A8K2Z9
    Related
    ENSP00000303350.5, ENST00000306042.9
    Conserved Domains (2) summary
    smart00194
    Location:76335
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:103335
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    127907053..128085855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448092.1XP_024303860.1  receptor-type tyrosine-protein phosphatase epsilon isoform X5

    Conserved Domains (2) summary
    smart00194
    Location:165424
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:484719
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_017016468.2XP_016871957.1  receptor-type tyrosine-protein phosphatase epsilon isoform X6

    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:453688
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_011539995.1XP_011538297.1  receptor-type tyrosine-protein phosphatase epsilon isoform X3

    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. XM_011539996.1XP_011538298.1  receptor-type tyrosine-protein phosphatase epsilon isoform X4

    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. XM_017016467.1XP_016871956.1  receptor-type tyrosine-protein phosphatase epsilon isoform X1

    Conserved Domains (2) summary
    smart00194
    Location:154413
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181413
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  6. XM_011539994.2XP_011538296.1  receptor-type tyrosine-protein phosphatase epsilon isoform X2

    Conserved Domains (2) summary
    smart00194
    Location:154412
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181412
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. XM_017016469.2XP_016871958.1  receptor-type tyrosine-protein phosphatase epsilon isoform X7

  8. XM_011539998.1XP_011538300.1  receptor-type tyrosine-protein phosphatase epsilon isoform X8

    Conserved Domains (2) summary
    smart00194
    Location:154355
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:181355
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  9. XM_005252691.2XP_005252748.1  receptor-type tyrosine-protein phosphatase epsilon isoform X6

    See identical proteins and their annotated locations for XP_005252748.1

    UniProtKB/Swiss-Prot
    P23469
    Conserved Domains (2) summary
    smart00194
    Location:134393
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:453688
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  10. XM_024448093.1XP_024303861.1  receptor-type tyrosine-protein phosphatase epsilon isoform X9

    Conserved Domains (2) summary
    smart00194
    Location:1173
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:233468
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. XR_002956995.1 RNA Sequence

  2. XR_002956996.1 RNA Sequence

    Related
    ENST00000479896.1
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