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ZNF410 zinc finger protein 410 [ Homo sapiens (human) ]

Gene ID: 57862, updated on 24-Nov-2020

Summary

Official Symbol
ZNF410provided by HGNC
Official Full Name
zinc finger protein 410provided by HGNC
Primary source
HGNC:HGNC:20144
See related
Ensembl:ENSG00000119725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APA1; APA-1
Expression
Ubiquitous expression in testis (RPKM 23.4), bone marrow (RPKM 18.5) and 25 other tissues See more
Orthologs

Genomic context

See ZNF410 in Genome Data Viewer
Location:
14q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (73886859..73932521)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74353318..74398991)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2274 Neighboring gene prostaglandin reductase 2 Neighboring gene FAM161 centrosomal protein B Neighboring gene coenzyme Q6, monooxygenase Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene ribosomal protein L41 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PTGR2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 410
Names
another partner for ARF 1
clones 23667 and 23775 zinc finger protein
zinc finger protein APA-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242924.2NP_001229853.1  zinc finger protein 410 isoform a

    See identical proteins and their annotated locations for NP_001229853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a)
    Source sequence(s)
    AA652386, AC005480, AC005520, AK293350
    Consensus CDS
    CCDS55929.1
    UniProtKB/Swiss-Prot
    Q86VK4
    Related
    ENSP00000407130.3, ENST00000442160.7
    Conserved Domains (4) summary
    sd00017
    Location:298320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:271290
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:342367
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:268351
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_001242926.2NP_001229855.1  zinc finger protein 410 isoform c

    See identical proteins and their annotated locations for NP_001229855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, and it also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA652386, AC005480, BC050683
    Consensus CDS
    CCDS55930.1
    UniProtKB/Swiss-Prot
    Q86VK4
    Related
    ENSP00000323293.6, ENST00000324593.10
    Conserved Domains (3) summary
    COG5048
    Location:148367
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:254273
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001242927.2NP_001229856.1  zinc finger protein 410 isoform d

    See identical proteins and their annotated locations for NP_001229856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 5' coding region, and it also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA652386, AC005480, AK299138
    Consensus CDS
    CCDS55931.1
    UniProtKB/Swiss-Prot
    Q86VK4
    Related
    ENSP00000442228.1, ENST00000540593.5
    Conserved Domains (4) summary
    sd00017
    Location:208230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:181200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:252277
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:178261
    zf-C2H2_8; C2H2-type zinc ribbon
  4. NM_001242928.2NP_001229857.1  zinc finger protein 410 isoform e

    See identical proteins and their annotated locations for NP_001229857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and 5' coding region, uses an alternate downstream start codon, and includes alternate exon structure in the 3' coding region, compared to variant 1. The encoded isoform (e) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AA652386, AC005480, BC000330, DC379519
    Related
    ENSP00000490985.1, ENST00000639051.1
    Conserved Domains (4) summary
    sd00017
    Location:85107
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:5877
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:129154
    zf-H2C2_2; Zinc-finger double domain
    pfam13900
    Location:276310
    GVQW; Putative domain of unknown function
  5. NM_021188.3NP_067011.1  zinc finger protein 410 isoform b

    See identical proteins and their annotated locations for NP_067011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and it also lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA652386, AC005480, AK223261
    Consensus CDS
    CCDS9821.1
    UniProtKB/Swiss-Prot
    Q86VK4
    UniProtKB/TrEMBL
    A0A024R691, Q53FM1
    Related
    ENSP00000451763.1, ENST00000555044.5
    Conserved Domains (4) summary
    sd00017
    Location:281303
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:254273
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:325350
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:251334
    zf-C2H2_8; C2H2-type zinc ribbon

RNA

  1. NR_040251.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon and uses an alternate splice site in the 5' region, and also lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA652386, AC005480, AK298520
    Related
    ENST00000398139.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    73886859..73932521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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