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CYP4F11 cytochrome P450 family 4 subfamily F member 11 [ Homo sapiens (human) ]

Gene ID: 57834, updated on 8-Jul-2021

Summary

Official Symbol
CYP4F11provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily F member 11provided by HGNC
Primary source
HGNC:HGNC:13265
See related
Ensembl:ENSG00000171903 MIM:611517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPIVF11
Summary
This gene, CYP4F11, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 19.6), gall bladder (RPKM 11.3) and 11 other tissues See more
Orthologs
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Genomic context

See CYP4F11 in Genome Data Viewer
Location:
19p13.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (15912377..15934867, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16023187..16045677, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene inositol polyphosphate multikinase pseudogene Neighboring gene olfactory receptor family 10 subfamily H member 4 Neighboring gene cytochrome P450 family 4 subfamily F member 9, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cytochrome P450, family 4, subfamily F, polypeptide 11 (CYP4F11) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in blood coagulation TAS
Traceable Author Statement
more info
PubMed 
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukotriene B4 catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in menaquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in menaquinone catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxylipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phylloquinone catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phylloquinone catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phylloquinone catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in vitamin K catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vitamin K catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 4F11
Names
3-hydroxy fatty acids omega-hydroxylase CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
cytochrome P450, subfamily IVF, polypeptide 11
docosahexaenoic acid omega-hydroxylase
long-chain fatty acid omega-monooxygenase
phylloquinone omega-hydroxylase CYP4F11
NP_001122404.1
NP_067010.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008335.1 RefSeqGene

    Range
    5001..27497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128932.2NP_001122404.1  cytochrome P450 4F11 precursor

    See identical proteins and their annotated locations for NP_001122404.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005336, AC011517, AC020950
    Consensus CDS
    CCDS12337.1
    UniProtKB/Swiss-Prot
    Q9HBI6
    Related
    ENSP00000248041.6, ENST00000248041.12
    Conserved Domains (1) summary
    pfam00067
    Location:52506
    p450; Cytochrome P450
  2. NM_021187.4NP_067010.3  cytochrome P450 4F11 precursor

    See identical proteins and their annotated locations for NP_067010.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AC005336, AC011517, AC020950
    Consensus CDS
    CCDS12337.1
    UniProtKB/Swiss-Prot
    Q9HBI6
    Related
    ENSP00000384588.2, ENST00000402119.9
    Conserved Domains (1) summary
    pfam00067
    Location:52506
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    15912377..15934867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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