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CATSPERG cation channel sperm associated auxiliary subunit gamma [ Homo sapiens (human) ]

Gene ID: 57828, updated on 19-Jun-2019

Summary

Official Symbol
CATSPERGprovided by HGNC
Official Full Name
cation channel sperm associated auxiliary subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:25243
See related
Ensembl:ENSG00000099338 MIM:613452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C19orf15
Summary
CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010]
Expression
Restricted expression toward testis (RPKM 11.5) See more
Orthologs

Genomic context

See CATSPERG in Genome Data Viewer
Location:
19q13.2
Exon count:
29
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38335830..38370943)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38826443..38861589)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene Sharpr-MPRA regulatory region 11361 Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene gametogenetin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Fertilization, organism-specific biosystem (from REACTOME)
    Fertilization, organism-specific biosystemMammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad c...
  • Reproduction, organism-specific biosystem (from REACTOME)
    Reproduction, organism-specific biosystemHuman reproduction mixes the genomes of two individuals creating a new organism. The offspring individuals produced by sexual reproduction differ from their parents and from their siblings. Reproduct...
  • Sperm Motility And Taxes, organism-specific biosystem (from REACTOME)
    Sperm Motility And Taxes, organism-specific biosystemA series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38899, FLJ46353, MGC125664, DKFZp434A1022

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
response to progesterone TAS
Traceable Author Statement
more info
 
sperm-egg recognition TAS
Traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CatSper complex ISS
Inferred from Sequence or Structural Similarity
more info
 
motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sperm principal piece IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cation channel sperm-associated protein subunit gamma
Names
catsper channel auxiliary subunit gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330496.2NP_001317425.1  cation channel sperm-associated protein subunit gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005625, AC005789, BC060889
    Consensus CDS
    CCDS82346.1
    UniProtKB/TrEMBL
    B8ZZI7
    Related
    ENSP00000387057.1, ENST00000410018.5
  2. NM_021185.5NP_067008.3  cation channel sperm-associated protein subunit gamma isoform 1 precursor

    See identical proteins and their annotated locations for NP_067008.3

    Status: VALIDATED

    Source sequence(s)
    AK128220, AW072458, BC060889, BC109035
    Consensus CDS
    CCDS12514.2
    UniProtKB/Swiss-Prot
    Q6ZRH7
    UniProtKB/TrEMBL
    Q32MQ2
    Related
    ENSP00000386962.3, ENST00000409235.8
    Conserved Domains (1) summary
    pfam15064
    Location:13976
    CATSPERG; Cation channel sperm-associated protein subunit gamma

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38335830..38370943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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