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HMHB1 histocompatibility minor HB-1 [ Homo sapiens (human) ]

Gene ID: 57824, updated on 11-Jun-2021

Summary

Official Symbol
HMHB1provided by HGNC
Official Full Name
histocompatibility minor HB-1provided by HGNC
Primary source
HGNC:HGNC:29677
See related
Ensembl:ENSG00000158497 MIM:609961
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB-1; HB-1Y; HLA-HB1
Summary
This gene encodes one of the minor histocompatibility antigens, which play an important role in the induction of cytotoxic T lymphocyte (CTL) reactivity against leukemia after human histocompatibility leukocyte antigen (HLA)-identical allogeneic bone marrow transplantation (BMT). This gene is only expressed in B cell acute lymphoblastic leukemia cells and Epstein-Barr virus-transformed B cells. The translation of this mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HMHB1 in Genome Data Viewer
Location:
5q31.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (143812161..143820716)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (143191726..143200281)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 5197 Neighboring gene TNF receptor associated factor 4 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 87, pseudogene Neighboring gene Yip1 domain family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General protein information

Preferred Names
minor histocompatibility protein HB-1
Names
minor histocompatibility antigen HB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021182.3NP_067005.1  minor histocompatibility protein HB-1

    See identical proteins and their annotated locations for NP_067005.1

    Status: REVIEWED

    Source sequence(s)
    AC025765
    Consensus CDS
    CCDS43376.1
    UniProtKB/Swiss-Prot
    O97980
    Related
    ENSP00000289448.3, ENST00000289448.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    143812161..143820716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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