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SLAMF7 SLAM family member 7 [ Homo sapiens (human) ]

Gene ID: 57823, updated on 3-Jun-2018
Official Symbol
SLAMF7provided by HGNC
Official Full Name
SLAM family member 7provided by HGNC
Primary source
HGNC:HGNC:21394
See related
Ensembl:ENSG00000026751 MIM:606625; Vega:OTTHUMG00000024008
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
19A; CS1; CD319; CRACC
Expression
Biased expression in lymph node (RPKM 22.3), appendix (RPKM 19.3) and 13 other tissues See more
Orthologs
See SLAMF7 in Genome Data Viewer
Location:
1q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (160739057..160754821)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160708865..160724611)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SET pseudogene 9 Neighboring gene CD48 molecule Neighboring gene uncharacterized LOC105371470 Neighboring gene lymphocyte antigen 9

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
natural killer cell activation NAS
Non-traceable Author Statement
more info
PubMed 
natural killer cell mediated cytotoxicity NAS
Non-traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
SLAM family member 7
Names
19A24 protein
CD2 subset 1
CD2-like receptor activating cytotoxic cells
membrane protein FOAP-12
novel LY9 (lymphocyte antigen 9) like protein
protein 19A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282588.1NP_001269517.1  SLAM family member 7 isoform b precursor

    See identical proteins and their annotated locations for NP_001269517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK298548, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS60323.1
    UniProtKB/Swiss-Prot
    Q9NQ25
    Related
    ENSP00000416592.2, ENST00000444090.6
    Conserved Domains (2) summary
    cd05775
    Location:31125
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    smart00410
    Location:27104
    IG_like; Immunoglobulin like
  2. NM_001282589.1NP_001269518.1  SLAM family member 7 isoform c precursor

    See identical proteins and their annotated locations for NP_001269518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AK298499, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS60322.1
    UniProtKB/Swiss-Prot
    Q9NQ25
    Related
    ENSP00000405605.2, ENST00000441662.6
    Conserved Domains (2) summary
    cd05775
    Location:31125
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    smart00410
    Location:27104
    IG_like; Immunoglobulin like
  3. NM_001282590.1NP_001269519.1  SLAM family member 7 isoform d

    See identical proteins and their annotated locations for NP_001269519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AL121985, AL834424, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS60324.1
    UniProtKB/Swiss-Prot
    Q9NQ25
    Related
    ENSP00000357021.3, OTTHUMP00000025679, ENST00000368042.7, OTTHUMT00000060466
  4. NM_001282591.1NP_001269520.1  SLAM family member 7 isoform e

    See identical proteins and their annotated locations for NP_001269520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a.
    Source sequence(s)
    AK301438, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS60325.1
    UniProtKB/Swiss-Prot
    Q9NQ25
    Related
    ENSP00000409965.2, ENST00000458602.6
  5. NM_001282592.1NP_001269521.1  SLAM family member 7 isoform f precursor

    See identical proteins and their annotated locations for NP_001269521.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (f, also known as CS1-S) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK290706, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS60321.1
    UniProtKB/Swiss-Prot
    Q9NQ25
    Related
    ENSP00000352281.4, OTTHUMP00000025678, ENST00000359331.8, OTTHUMT00000060465
    Conserved Domains (1) summary
    cl11960
    Location:31125
    Ig; Immunoglobulin domain
  6. NM_001282593.1NP_001269522.1  SLAM family member 7 isoform g

    See identical proteins and their annotated locations for NP_001269522.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region, and also lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK301137, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS72956.1
    UniProtKB/TrEMBL
    B4DVL7
    Related
    ENSP00000403294.2, ENST00000458104.6
  7. NM_001282594.1NP_001269523.1  SLAM family member 7 isoform h

    See identical proteins and their annotated locations for NP_001269523.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AK301432, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS72957.1
    UniProtKB/TrEMBL
    B4DW98
    Related
    ENSP00000483774.1, ENST00000621377.4
  8. NM_001282595.1NP_001269524.1  SLAM family member 7 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks a portion of the 5' UTR and 5' coding region, and uses a downstream in-frame translational start codon, compared to variant 1. The encoded isoform (i) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AB027233, AL121985, BQ000581, DA978435, DA978525
    UniProtKB/Swiss-Prot
    Q9NQ25
  9. NM_001282596.1NP_001269525.1  SLAM family member 7 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks an alternate in-frame exon in the 5' coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (j) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL121985, BQ000581, DA644251, DA978435, DC388332
  10. NM_021181.4NP_067004.3  SLAM family member 7 isoform a precursor

    See identical proteins and their annotated locations for NP_067004.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as CS1-L).
    Source sequence(s)
    AB027233, AL121985, BQ000581, DA978435, DC388332
    Consensus CDS
    CCDS1209.1
    UniProtKB/Swiss-Prot
    Q9NQ25
    Related
    ENSP00000357022.3, OTTHUMP00000025677, ENST00000368043.7, OTTHUMT00000060464
    Conserved Domains (2) summary
    cd05775
    Location:31125
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    smart00410
    Location:27104
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    160739057..160754821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448757.1XP_024304525.1  SLAM family member 7 isoform X1

    Conserved Domains (1) summary
    cd16842
    Location:31125
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family
  2. XM_011509828.1XP_011508130.1  SLAM family member 7 isoform X2

    Conserved Domains (2) summary
    cd05775
    Location:31125
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    smart00410
    Location:27104
    IG_like; Immunoglobulin like
  3. XM_011509829.1XP_011508131.1  SLAM family member 7 isoform X3

    Conserved Domains (2) summary
    cd05775
    Location:31125
    Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
    smart00410
    Location:27104
    IG_like; Immunoglobulin like
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