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CCDC181 coiled-coil domain containing 181 [ Homo sapiens (human) ]

Gene ID: 57821, updated on 21-Dec-2019

Summary

Official Symbol
CCDC181provided by HGNC
Official Full Name
coiled-coil domain containing 181provided by HGNC
Primary source
HGNC:HGNC:28051
See related
Ensembl:ENSG00000117477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf114
Expression
Biased expression in testis (RPKM 7.3), kidney (RPKM 1.3) and 7 other tissues See more
Orthologs

Genomic context

See CCDC181 in Genome Data Viewer
Location:
1q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (169394870..169462221, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169364108..169429907, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 1 Neighboring gene NME/NM23 family member 7 Neighboring gene uncharacterized LOC105371605 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene solute carrier family 19 member 2 Neighboring gene Sharpr-MPRA regulatory region 2803 Neighboring gene coagulation factor V

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
manchette ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 181

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300968.1NP_001287897.1  coiled-coil domain-containing protein 181 isoform a

    See identical proteins and their annotated locations for NP_001287897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK313598, AL049687, BG206257
    Consensus CDS
    CCDS1279.1
    UniProtKB/Swiss-Prot
    Q5TID7
    UniProtKB/TrEMBL
    B2R917
    Related
    ENSP00000442297.1, ENST00000545005.5
    Conserved Domains (1) summary
    pfam13904
    Location:338460
    DUF4207; Domain of unknown function (DUF4207)
  2. NM_001300969.1NP_001287898.1  coiled-coil domain-containing protein 181 isoform b

    See identical proteins and their annotated locations for NP_001287898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AK223354, AL049687, BC026073, BG206257
    Consensus CDS
    CCDS72979.1
    UniProtKB/Swiss-Prot
    Q5TID7
    Related
    ENSP00000356780.3, ENST00000367806.7
    Conserved Domains (1) summary
    pfam13904
    Location:338461
    DUF4207; Domain of unknown function (DUF4207)
  3. NM_021179.2NP_067002.1  coiled-coil domain-containing protein 181 isoform a

    See identical proteins and their annotated locations for NP_067002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL049687, BC026073, BG206257
    Consensus CDS
    CCDS1279.1
    UniProtKB/Swiss-Prot
    Q5TID7
    Related
    ENSP00000356779.3, ENST00000367805.7
    Conserved Domains (1) summary
    pfam13904
    Location:338460
    DUF4207; Domain of unknown function (DUF4207)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    169394870..169462221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001938.1XP_016857427.1  coiled-coil domain-containing protein 181 isoform X1

    UniProtKB/Swiss-Prot
    Q5TID7
    Conserved Domains (1) summary
    pfam13904
    Location:338461
    DUF4207; Domain of unknown function (DUF4207)
  2. XM_005245383.1XP_005245440.1  coiled-coil domain-containing protein 181 isoform X1

    See identical proteins and their annotated locations for XP_005245440.1

    UniProtKB/Swiss-Prot
    Q5TID7
    Conserved Domains (1) summary
    pfam13904
    Location:338461
    DUF4207; Domain of unknown function (DUF4207)
  3. XM_017001939.1XP_016857428.1  coiled-coil domain-containing protein 181 isoform X1

    UniProtKB/Swiss-Prot
    Q5TID7
    Conserved Domains (1) summary
    pfam13904
    Location:338461
    DUF4207; Domain of unknown function (DUF4207)
  4. XM_017001940.1XP_016857429.1  coiled-coil domain-containing protein 181 isoform X2

    UniProtKB/Swiss-Prot
    Q5TID7
    Conserved Domains (1) summary
    pfam13904
    Location:338460
    DUF4207; Domain of unknown function (DUF4207)
  5. XM_011509827.2XP_011508129.1  coiled-coil domain-containing protein 181 isoform X1

    See identical proteins and their annotated locations for XP_011508129.1

    UniProtKB/Swiss-Prot
    Q5TID7
    Conserved Domains (1) summary
    pfam13904
    Location:338461
    DUF4207; Domain of unknown function (DUF4207)
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