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CCDC181 coiled-coil domain containing 181 [ Homo sapiens (human) ]

Gene ID: 57821, updated on 3-Apr-2024

Summary

Official Symbol
CCDC181provided by HGNC
Official Full Name
coiled-coil domain containing 181provided by HGNC
Primary source
HGNC:HGNC:28051
See related
Ensembl:ENSG00000117477 AllianceGenome:HGNC:28051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf114
Summary
Predicted to enable microtubule binding activity. Predicted to be located in manchette and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 7.3), kidney (RPKM 1.3) and 7 other tissues See more
Orthologs
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Genomic context

See CCDC181 in Genome Data Viewer
Location:
1q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169394870..169460669, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (168750193..168816015, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169364108..169429907, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169074345-169074918 Neighboring gene Sharpr-MPRA regulatory region 5967 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:169076065-169076637 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:169082217-169083416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:169085415-169086034 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2070 Neighboring gene NME/NM23 family member 7 Neighboring gene NANOG hESC enhancer GRCh37_chr1:169185155-169185723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169225944-169226549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169226550-169227154 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:169336872-169338071 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1546 Neighboring gene Sharpr-MPRA regulatory region 5964 Neighboring gene solute carrier family 19 member 2 Neighboring gene MPRA-validated peak447 silencer Neighboring gene MPRA-validated peak448 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1250 Neighboring gene MPRA-validated peak449 silencer Neighboring gene Sharpr-MPRA regulatory region 2803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:169555193-169555694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:169555695-169556194 Neighboring gene coagulation factor V

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ25846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in manchette ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
coiled-coil domain-containing protein 181

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300968.1NP_001287897.1  coiled-coil domain-containing protein 181 isoform a

    See identical proteins and their annotated locations for NP_001287897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK313598, AL049687, BG206257
    Consensus CDS
    CCDS1279.1
    UniProtKB/TrEMBL
    B2R917
    Related
    ENSP00000442297.1, ENST00000545005.5
    Conserved Domains (1) summary
    pfam13904
    Location:338460
    DUF4207; Domain of unknown function (DUF4207)
  2. NM_001300969.2NP_001287898.1  coiled-coil domain-containing protein 181 isoform b

    See identical proteins and their annotated locations for NP_001287898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AK223354, AL049687, BC026073, BG206257
    Consensus CDS
    CCDS72979.1
    UniProtKB/Swiss-Prot
    O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
    UniProtKB/TrEMBL
    B2R917
    Related
    ENSP00000356780.3, ENST00000367806.8
    Conserved Domains (1) summary
    pfam17380
    Location:338500
    DUF5401; Family of unknown function (DUF5401)
  3. NM_001394007.1NP_001380936.1  coiled-coil domain-containing protein 181 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL021068
    Consensus CDS
    CCDS72979.1
    UniProtKB/Swiss-Prot
    O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
    UniProtKB/TrEMBL
    B2R917
    Conserved Domains (1) summary
    pfam17380
    Location:338500
    DUF5401; Family of unknown function (DUF5401)
  4. NM_001394008.1NP_001380937.1  coiled-coil domain-containing protein 181 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL021068
    Consensus CDS
    CCDS1279.1
    UniProtKB/TrEMBL
    B2R917
  5. NM_001394009.1NP_001380938.1  coiled-coil domain-containing protein 181 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL021068
    UniProtKB/TrEMBL
    X6RJ50
    Related
    ENST00000491570.2
  6. NM_021179.3NP_067002.1  coiled-coil domain-containing protein 181 isoform a

    See identical proteins and their annotated locations for NP_067002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL049687, BC026073, BG206257
    Consensus CDS
    CCDS1279.1
    UniProtKB/TrEMBL
    B2R917
    Related
    ENSP00000356779.3, ENST00000367805.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    169394870..169460669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245383.1XP_005245440.1  coiled-coil domain-containing protein 181 isoform X1

    See identical proteins and their annotated locations for XP_005245440.1

    UniProtKB/Swiss-Prot
    O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
    UniProtKB/TrEMBL
    B2R917
    Conserved Domains (1) summary
    pfam17380
    Location:338500
    DUF5401; Family of unknown function (DUF5401)
  2. XM_017001938.2XP_016857427.1  coiled-coil domain-containing protein 181 isoform X1

    UniProtKB/Swiss-Prot
    O60780, Q53FD5, Q5TID7, Q5TID9, Q8TC48
    UniProtKB/TrEMBL
    B2R917
    Conserved Domains (1) summary
    pfam17380
    Location:338500
    DUF5401; Family of unknown function (DUF5401)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    168750193..168816015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337933.1XP_054193908.1  coiled-coil domain-containing protein 181 isoform X1

  2. XM_054337932.1XP_054193907.1  coiled-coil domain-containing protein 181 isoform X1