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BRINP2 BMP/retinoic acid inducible neural specific 2 [ Homo sapiens (human) ]

Gene ID: 57795, updated on 2-May-2024

Summary

Official Symbol
BRINP2provided by HGNC
Official Full Name
BMP/retinoic acid inducible neural specific 2provided by HGNC
Primary source
HGNC:HGNC:13746
See related
Ensembl:ENSG00000198797 MIM:619359; AllianceGenome:HGNC:13746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM5B; DBCCR1L2
Summary
Predicted to be involved in cellular response to retinoic acid; negative regulation of mitotic cell cycle; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Implicated in oral squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 11.7), adrenal (RPKM 4.6) and 1 other tissue See more
Orthologs
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Genomic context

See BRINP2 in Genome Data Viewer
Location:
1q25.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (177170958..177282422)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (176525633..176637111)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (177140094..177251558)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pappalysin 2 Neighboring gene PTP4A1 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:176694898-176695118 Neighboring gene NANOG hESC enhancer GRCh37_chr1:176702698-176703199 Neighboring gene MPRA-validated peak474 silencer Neighboring gene GATA motif-containing MPRA enhancer 65 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:176873029-176873530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:176873531-176874030 Neighboring gene astrotactin 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:177013479-177014043 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:177017656-177018356 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:177029877-177031076 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:177034489-177035123 Neighboring gene microRNA 488 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:177139732-177140321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:177140322-177140910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:177150672-177151233 Neighboring gene uncharacterized LOC105371625 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:177224616-177225815 Neighboring gene long intergenic non-protein coding RNA 1645 Neighboring gene NANOG hESC enhancer GRCh37_chr1:177624802-177625303 Neighboring gene long intergenic non-protein coding RNA 1741

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 5, member B (FAM5B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ41342, KIAA1747

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in central nervous system neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
BMP/retinoic acid-inducible neural-specific protein 2
Names
DBCCR1-like protein 2
DBCCR1-like2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
bone morphogenic protein/retinoic acid inducible neural-specific 2
family with sequence similarity 5, member B
protein FAM5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021165.4NP_066988.1  BMP/retinoic acid-inducible neural-specific protein 2 precursor

    See identical proteins and their annotated locations for NP_066988.1

    Status: VALIDATED

    Source sequence(s)
    AB051534, AB161694, AL021398, AL022143, DA118275
    Consensus CDS
    CCDS1320.1
    UniProtKB/Swiss-Prot
    O95560, Q6ZWC1, Q7LCZ9, Q8N360, Q9C0B6
    Related
    ENSP00000354481.4, ENST00000361539.5
    Conserved Domains (1) summary
    smart00457
    Location:90281
    MACPF; membrane-attack complex / perforin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    177170958..177282422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245379.3XP_005245436.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005245436.1

    UniProtKB/Swiss-Prot
    O95560, Q6ZWC1, Q7LCZ9, Q8N360, Q9C0B6
    Conserved Domains (1) summary
    smart00457
    Location:90281
    MACPF; membrane-attack complex / perforin
  2. XM_024448722.2XP_024304490.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95560, Q6ZWC1, Q7LCZ9, Q8N360, Q9C0B6
    Conserved Domains (1) summary
    smart00457
    Location:90281
    MACPF; membrane-attack complex / perforin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    176525633..176637111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337928.1XP_054193903.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

  2. XM_054337929.1XP_054193904.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1