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BRINP2 BMP/retinoic acid inducible neural specific 2 [ Homo sapiens (human) ]

Gene ID: 57795, updated on 8-Mar-2025

Summary

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Official Symbol
BRINP2provided by HGNC
Official Full Name
BMP/retinoic acid inducible neural specific 2provided by HGNC
Primary source
HGNC:HGNC:13746
See related
Ensembl:ENSG00000198797 MIM:619359; AllianceGenome:HGNC:13746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM5B; DBCCR1L2
Summary
Predicted to be involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within locomotion and nervous system development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Implicated in oral squamous cell carcinoma. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Biased expression in brain (RPKM 11.7), adrenal (RPKM 4.6) and 1 other tissue See more
Orthologs
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Genomic context

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See BRINP2 in Genome Data Viewer
Location:
1q25.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (177170958..177282422)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (176525633..176637111)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (177140094..177251558)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pappalysin 2 Neighboring gene PTP4A1 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:176694898-176695118 Neighboring gene NANOG hESC enhancer GRCh37_chr1:176702698-176703199 Neighboring gene MPRA-validated peak474 silencer Neighboring gene GATA motif-containing MPRA enhancer 65 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:176873029-176873530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:176873531-176874030 Neighboring gene astrotactin 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:177013479-177014043 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:177017656-177018356 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:177029877-177031076 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:177034489-177035123 Neighboring gene microRNA 488 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:177139732-177140321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:177140322-177140910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:177150672-177151233 Neighboring gene uncharacterized LOC105371625 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:177224616-177225815 Neighboring gene long intergenic non-protein coding RNA 1645 Neighboring gene NANOG hESC enhancer GRCh37_chr1:177624802-177625303 Neighboring gene long intergenic non-protein coding RNA 1741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. Kawano H, et al. Brain Res Mol Brain Res, 2004 Jun 18. PMID 15193423
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Dec 31. PMID 11214970
  3. Identification of host proteins required for HIV infection through a functional genomic screen. Brass AL, et al. Science, 2008 Feb 15. PMID 18187620
  4. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article
  5. A "double adaptor" method for improved shotgun library construction. Andersson B, et al. Anal Biochem, 1996 Apr 5. PMID 8619474

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 5, member B (FAM5B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41342, KIAA1747

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to retinoic acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in locomotion IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BMP/retinoic acid-inducible neural-specific protein 2
Names
DBCCR1-like protein 2
DBCCR1-like2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
bone morphogenic protein/retinoic acid inducible neural-specific 2
family with sequence similarity 5, member B
protein FAM5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021165.4 → NP_066988.1  BMP/retinoic acid-inducible neural-specific protein 2 precursor

    See identical proteins and their annotated locations for NP_066988.1

    Status: VALIDATED

    Source sequence(s)
    AB051534, AB161694, AL021398, AL022143, DA118275
    Consensus CDS
    CCDS1320.1
    UniProtKB/Swiss-Prot
    O95560, Q6ZWC1, Q7LCZ9, Q8N360, Q9C0B6
    Related
    ENSP00000354481.4, ENST00000361539.5
    Conserved Domains (1) summary
    smart00457
    Location:90 → 281
    MACPF; membrane-attack complex / perforin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    177170958..177282422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245379.3 → XP_005245436.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005245436.1

    UniProtKB/Swiss-Prot
    O95560, Q6ZWC1, Q7LCZ9, Q8N360, Q9C0B6
    Conserved Domains (1) summary
    smart00457
    Location:90 → 281
    MACPF; membrane-attack complex / perforin

  2. XM_024448722.2 → XP_024304490.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O95560, Q6ZWC1, Q7LCZ9, Q8N360, Q9C0B6
    Conserved Domains (1) summary
    smart00457
    Location:90 → 281
    MACPF; membrane-attack complex / perforin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    176525633..176637111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337928.1 → XP_054193903.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

  2. XM_054337929.1 → XP_054193904.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0B6.2 GenPept UniProtKB/Swiss-Prot:Q9C0B6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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