U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BRINP2 BMP/retinoic acid inducible neural specific 2 [ Homo sapiens (human) ]

Gene ID: 57795, updated on 8-Dec-2022

Summary

Official Symbol
BRINP2provided by HGNC
Official Full Name
BMP/retinoic acid inducible neural specific 2provided by HGNC
Primary source
HGNC:HGNC:13746
See related
Ensembl:ENSG00000198797 MIM:619359; AllianceGenome:HGNC:13746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM5B; DBCCR1L2
Summary
Predicted to be involved in cellular response to retinoic acid; negative regulation of mitotic cell cycle; and positive regulation of neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in dendrite; endoplasmic reticulum; and neuronal cell body. Implicated in oral squamous cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 11.7), adrenal (RPKM 4.6) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See BRINP2 in Genome Data Viewer
Location:
1q25.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (177170958..177282422)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (176525633..176637111)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (177140094..177251558)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GATA motif-containing MPRA enhancer 65 Neighboring gene astrotactin 1 Neighboring gene microRNA 488 Neighboring gene uncharacterized LOC105371625 Neighboring gene long intergenic non-protein coding RNA 1645 Neighboring gene long intergenic non-protein coding RNA 1741

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of family with sequence similarity 5, member B (FAM5B) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41342, KIAA1747

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BMP/retinoic acid-inducible neural-specific protein 2
Names
DBCCR1-like protein 2
DBCCR1-like2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
bone morphogenic protein/retinoic acid inducible neural-specific 2
family with sequence similarity 5, member B
protein FAM5B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021165.4NP_066988.1  BMP/retinoic acid-inducible neural-specific protein 2 precursor

    See identical proteins and their annotated locations for NP_066988.1

    Status: VALIDATED

    Source sequence(s)
    AB051534, AB161694, AL021398, AL022143, DA118275
    Consensus CDS
    CCDS1320.1
    UniProtKB/Swiss-Prot
    Q8N360, Q9C0B6
    Related
    ENSP00000354481.4, ENST00000361539.5
    Conserved Domains (1) summary
    smart00457
    Location:90281
    MACPF; membrane-attack complex / perforin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    177170958..177282422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245379.3XP_005245436.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005245436.1

    UniProtKB/Swiss-Prot
    Q8N360, Q9C0B6
    Conserved Domains (1) summary
    smart00457
    Location:90281
    MACPF; membrane-attack complex / perforin
  2. XM_024448722.2XP_024304490.1  BMP/retinoic acid-inducible neural-specific protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8N360
    Conserved Domains (1) summary
    smart00457
    Location:90281
    MACPF; membrane-attack complex / perforin

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    176525633..176637111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)