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PTPN7 protein tyrosine phosphatase, non-receptor type 7 [ Homo sapiens (human) ]

Gene ID: 5778, updated on 8-Dec-2018

Summary

Official Symbol
PTPN7provided by HGNC
Official Full Name
protein tyrosine phosphatase, non-receptor type 7provided by HGNC
Primary source
HGNC:HGNC:9659
See related
Ensembl:ENSG00000143851 MIM:176889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Biased expression in bone marrow (RPKM 19.6), lymph node (RPKM 18.1) and 11 other tissues See more
Orthologs

Genomic context

See PTPN7 in Genome Data Viewer
Location:
1q32.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (202147012..202161588, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202116141..202130716, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371683 Neighboring gene G protein-coupled receptor 37 like 1 Neighboring gene ADP ribosylation factor like GTPase 8A Neighboring gene protein tyrosine phosphatase, receptor type V, pseudogene Neighboring gene leucine rich repeat containing G protein-coupled receptor 6 Neighboring gene uncharacterized LOC101929388

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18703

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 7
Names
dual specificity phosphatase 1
hematopoietic protein-tyrosine phosphatase
protein-tyrosine phosphatase LC-PTP
protein-tyrosine phosphatase, nonreceptor-type, stress induced
NP_001186726.1
NP_002823.3
NP_542155.1
XP_011508121.1
XP_011508122.1
XP_011508123.1
XP_011508124.1
XP_011508125.1
XP_011508126.1
XP_016857424.1
XP_016857425.1
XP_016857426.1
XP_024304479.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199797.1NP_001186726.1  tyrosine-protein phosphatase non-receptor type 7 isoform 3

    See identical proteins and their annotated locations for NP_001186726.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' region, resulting in an upstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK302869, AL592300, DC399028
    UniProtKB/TrEMBL
    B4DZD9
    Related
    ENSP00000418416.1, ENST00000477554.5
    Conserved Domains (2) summary
    smart00194
    Location:170422
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:196422
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001364877.1NP_001351806.1  tyrosine-protein phosphatase non-receptor type 7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL592300
    Conserved Domains (1) summary
    cd00047
    Location:121347
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_001364878.1NP_001351807.1  tyrosine-protein phosphatase non-receptor type 7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL592300, BT009848, DC399028
    Conserved Domains (1) summary
    cd00047
    Location:122348
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. NM_002832.3NP_002823.3  tyrosine-protein phosphatase non-receptor type 7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK225920, AL592300
    Consensus CDS
    CCDS1423.2
    UniProtKB/Swiss-Prot
    P35236
    Related
    ENSP00000309116.3, ENST00000309017.7
    Conserved Domains (2) summary
    smart00194
    Location:201453
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:227453
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_080588.2NP_542155.1  tyrosine-protein phosphatase non-receptor type 7 isoform 2

    See identical proteins and their annotated locations for NP_542155.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon from the 5' end and contains an alternate 5' segment which includes an AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL592300, BC001746
    Consensus CDS
    CCDS1422.1
    UniProtKB/Swiss-Prot
    P35236
    UniProtKB/TrEMBL
    A0A024R9A7
    Related
    ENSP00000356248.4, ENST00000367279.8
    Conserved Domains (2) summary
    smart00194
    Location:135387
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:161387
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. NR_037663.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the CDS, resulting in frame-shift and a premature stop codon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and probably does not make a functional protein.
    Source sequence(s)
    AK301051, AL592300
  2. NR_037664.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon in the CDS, resulting in frame-shift and a premature stop codon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and probably does not make a functional protein.
    Source sequence(s)
    AK293186, AL592300

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    202147012..202161588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001937.1XP_016857426.1  tyrosine-protein phosphatase non-receptor type 7 isoform X7

    Conserved Domains (1) summary
    cd00047
    Location:121347
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. XM_024448711.1XP_024304479.1  tyrosine-protein phosphatase non-receptor type 7 isoform X4

    Conserved Domains (1) summary
    cd00047
    Location:122394
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. XM_011509820.2XP_011508122.1  tyrosine-protein phosphatase non-receptor type 7 isoform X5

    Conserved Domains (2) summary
    smart00194
    Location:90388
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:116388
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  4. XM_017001936.1XP_016857425.1  tyrosine-protein phosphatase non-receptor type 7 isoform X3

  5. XM_017001935.1XP_016857424.1  tyrosine-protein phosphatase non-receptor type 7 isoform X2

  6. XM_011509819.1XP_011508121.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

    Conserved Domains (2) summary
    smart00194
    Location:201499
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:227499
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  7. XM_011509824.1XP_011508126.1  tyrosine-protein phosphatase non-receptor type 7 isoform X9

    Conserved Domains (2) summary
    cd00047
    Location:1223
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:1223
    Y_phosphatase; Protein-tyrosine phosphatase
  8. XM_011509821.1XP_011508123.1  tyrosine-protein phosphatase non-receptor type 7 isoform X6

    See identical proteins and their annotated locations for XP_011508123.1

    Conserved Domains (2) summary
    smart00194
    Location:44342
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:70342
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  9. XM_011509822.2XP_011508124.1  tyrosine-protein phosphatase non-receptor type 7 isoform X6

    See identical proteins and their annotated locations for XP_011508124.1

    Conserved Domains (2) summary
    smart00194
    Location:44342
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:70342
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  10. XM_011509823.1XP_011508125.1  tyrosine-protein phosphatase non-receptor type 7 isoform X8

    Conserved Domains (2) summary
    smart00194
    Location:201307
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cl21483
    Location:227307
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

  1. XR_921906.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_080589.1: Suppressed sequence

    Description
    NM_080589.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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