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SCUBE2 signal peptide, CUB domain and EGF like domain containing 2 [ Homo sapiens (human) ]

Gene ID: 57758, updated on 22-Aug-2020

Summary

Official Symbol
SCUBE2provided by HGNC
Official Full Name
signal peptide, CUB domain and EGF like domain containing 2provided by HGNC
Primary source
HGNC:HGNC:30425
See related
Ensembl:ENSG00000175356 MIM:611747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEGB1; CEGF1; CEGP1; scube/You
Expression
Broad expression in prostate (RPKM 8.1), urinary bladder (RPKM 7.3) and 20 other tissues See more
Orthologs

Genomic context

See SCUBE2 in Genome Data Viewer
Location:
11p15.4
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (9019476..9091599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9041047..9113150, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TMEM9 domain family member B Neighboring gene TMEM9B antisense RNA 1 Neighboring gene nuclear receptor interacting protein 3 Neighboring gene uncharacterized LOC105376541 Neighboring gene microRNA 5691 Neighboring gene keratin 8 pseudogene 41 Neighboring gene uncharacterized LOC105376542

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16792, FLJ35234, MGC133057

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
signal peptide, CUB and EGF-like domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170690.3NP_001164161.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001164161.1

    Status: VALIDATED

    Source sequence(s)
    AC079296, AK123039, AL133990, BC111690
    Consensus CDS
    CCDS53599.1
    UniProtKB/Swiss-Prot
    Q9NQ36
    Related
    ENSP00000415187.2, ENST00000450649.6
    Conserved Domains (4) summary
    pfam07699
    Location:631678
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_001330199.3NP_001317128.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC079296, AK092553, AL133990, DA739146, DA999556, DB002185, DB004372
    Consensus CDS
    CCDS81553.1
    UniProtKB/Swiss-Prot
    Q9NQ36
    UniProtKB/TrEMBL
    B3KS09
    Related
    ENSP00000310658.3, ENST00000309263.7
    Conserved Domains (5) summary
    cd00041
    Location:809920
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:757804
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. NM_001367977.2NP_001354906.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC079296, KF459545
    Related
    ENSP00000497523.1, ENST00000649792.1
  4. NM_020974.4NP_066025.2  signal peptide, CUB and EGF-like domain-containing protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_066025.2

    Status: VALIDATED

    Source sequence(s)
    AC079296, AK123039, AL133990, BC111690
    Consensus CDS
    CCDS7797.2
    UniProtKB/Swiss-Prot
    Q9NQ36
    UniProtKB/TrEMBL
    A0A0A0MTC8
    Related
    ENSP00000429969.1, ENST00000520467.5
    Conserved Domains (5) summary
    cd00041
    Location:781892
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:729776
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    9019476..9091599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253036.4XP_005253093.2  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X7

    See identical proteins and their annotated locations for XP_005253093.2

    Conserved Domains (5) summary
    cd00041
    Location:729840
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:677724
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:286321
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. XM_017018081.1XP_016873570.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X8

  3. XM_017018080.1XP_016873569.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X5

  4. XM_005253034.4XP_005253091.2  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X2

    Conserved Domains (5) summary
    cd00041
    Location:797908
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:745792
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:286321
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  5. XM_005253037.4XP_005253094.2  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X9

    Conserved Domains (5) summary
    cd00041
    Location:683794
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:631678
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  6. XM_011520247.2XP_011518549.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X4

    Conserved Domains (5) summary
    cd00041
    Location:770881
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:718765
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  7. XM_011520246.2XP_011518548.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    pfam07699
    Location:786833
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  8. XM_017018082.2XP_016873571.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X10

  9. XM_005253035.4XP_005253092.2  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X6

    Conserved Domains (5) summary
    cd00041
    Location:838949
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam07699
    Location:786833
    GCC2_GCC3; GCC2 and GCC3
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  10. XM_011520248.2XP_011518550.1  signal peptide, CUB and EGF-like domain-containing protein 2 isoform X11

    Conserved Domains (3) summary
    pfam12947
    Location:4984
    EGF_3; EGF domain
    pfam14670
    Location:407442
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:312361
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
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