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IGDCC4 immunoglobulin superfamily DCC subclass member 4 [ Homo sapiens (human) ]

Gene ID: 57722, updated on 1-Jun-2020

Summary

Official Symbol
IGDCC4provided by HGNC
Official Full Name
immunoglobulin superfamily DCC subclass member 4provided by HGNC
Primary source
HGNC:HGNC:13770
See related
Ensembl:ENSG00000103742 MIM:616810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NOPE; DDM36
Expression
Broad expression in ovary (RPKM 6.3), placenta (RPKM 5.2) and 17 other tissues See more
Orthologs

Genomic context

See IGDCC4 in Genome Data Viewer
Location:
15q22.31
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65381484..65422947, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65673825..65715410, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, U5B small nuclear 1 Neighboring gene immunoglobulin superfamily DCC subclass member 3 Neighboring gene dipeptidyl peptidase 8 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene RNA, U6 small nuclear 19, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42051, KIAA1628

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
immunoglobulin superfamily DCC subclass member 4
Names
likely ortholog of mouse neighbor of Punc E11
neighbor of Punc E11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020962.3NP_066013.1  immunoglobulin superfamily DCC subclass member 4 precursor

    See identical proteins and their annotated locations for NP_066013.1

    Status: VALIDATED

    Source sequence(s)
    AB052622, AC105129
    Consensus CDS
    CCDS10206.1
    UniProtKB/Swiss-Prot
    Q8TDY8
    Related
    ENSP00000319623.3, ENST00000352385.3
    Conserved Domains (6) summary
    smart00408
    Location:156218
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:149230
    IG_like; Immunoglobulin like
    cd00063
    Location:850942
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:335422
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:430515
    fn3; Fibronectin type III domain
    cl11960
    Location:350422
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65381484..65422947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521846.3XP_011520148.1  immunoglobulin superfamily DCC subclass member 4 isoform X3

    Related
    ENST00000559327.1
    Conserved Domains (6) summary
    smart00408
    Location:156218
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:149230
    IG_like; Immunoglobulin like
    cd00063
    Location:851943
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:335422
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:430515
    fn3; Fibronectin type III domain
    cl11960
    Location:350422
    Ig; Immunoglobulin domain
  2. XM_011521847.2XP_011520149.1  immunoglobulin superfamily DCC subclass member 4 isoform X4

    Conserved Domains (6) summary
    smart00408
    Location:155
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:169
    IG_like; Immunoglobulin like
    cd00063
    Location:589681
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:73160
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:168253
    fn3; Fibronectin type III domain
    cl11960
    Location:88160
    Ig; Immunoglobulin domain
  3. XM_017022448.2XP_016877937.1  immunoglobulin superfamily DCC subclass member 4 isoform X1

  4. XM_011521845.3XP_011520147.1  immunoglobulin superfamily DCC subclass member 4 isoform X2

    Conserved Domains (6) summary
    smart00408
    Location:169231
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:162243
    IG_like; Immunoglobulin like
    cd00063
    Location:863955
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:348435
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:443528
    fn3; Fibronectin type III domain
    cl11960
    Location:363435
    Ig; Immunoglobulin domain
  5. XM_017022449.1XP_016877938.1  immunoglobulin superfamily DCC subclass member 4 isoform X5

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