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METTL14 methyltransferase 14, N6-adenosine-methyltransferase subunit [ Homo sapiens (human) ]

Gene ID: 57721, updated on 25-Jan-2022

Summary

Official Symbol
METTL14provided by HGNC
Official Full Name
methyltransferase 14, N6-adenosine-methyltransferase subunitprovided by HGNC
Primary source
HGNC:HGNC:29330
See related
Ensembl:ENSG00000145388 MIM:616504; AllianceGenome:HGNC:29330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hMETTL14
Summary
Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis (RPKM 8.4), thyroid (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See METTL14 in Genome Data Viewer
Location:
4q26
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (118685375..118715430)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (119606547..119636585)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene septin 14 pseudogene 4 Neighboring gene METTL14 divergent transcript Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene Sharpr-MPRA regulatory region 11880 Neighboring gene uncharacterized LOC105377393 Neighboring gene synaptopodin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1627

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in forebrain radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gliogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N6-adenosine-methyltransferase non-catalytic subunit
Names
N6-adenosine-methyltransferase subunit METTL14
methyltransferase like 14
methyltransferase-like protein 14
NP_066012.1
XP_005263223.1
XP_011530464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020961.4NP_066012.1  N6-adenosine-methyltransferase non-catalytic subunit

    See identical proteins and their annotated locations for NP_066012.1

    Status: VALIDATED

    Source sequence(s)
    AB046847, AC110079, AW206149, BG773151
    Consensus CDS
    CCDS34053.1
    UniProtKB/Swiss-Prot
    Q9HCE5
    Related
    ENSP00000373474.3, ENST00000388822.10
    Conserved Domains (1) summary
    pfam05063
    Location:186363
    MT-A70

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    118685375..118715430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532162.2XP_011530464.1  N6-adenosine-methyltransferase non-catalytic subunit isoform X2

    Conserved Domains (1) summary
    cl01947
    Location:186246
    MT-A70; MT-A70
  2. XM_005263166.4XP_005263223.1  N6-adenosine-methyltransferase non-catalytic subunit isoform X1

    Conserved Domains (1) summary
    cl01947
    Location:186285
    MT-A70; MT-A70

RNA

  1. XR_938769.2 RNA Sequence

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