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GPR107 G protein-coupled receptor 107 [ Homo sapiens (human) ]

Gene ID: 57720, updated on 4-Jul-2021

Summary

Official Symbol
GPR107provided by HGNC
Official Full Name
G protein-coupled receptor 107provided by HGNC
Primary source
HGNC:HGNC:17830
See related
Ensembl:ENSG00000148358 MIM:618490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCDRP; LUSTR1; bA138E2.2
Expression
Ubiquitous expression in thyroid (RPKM 20.9), brain (RPKM 13.5) and 25 other tissues See more
Orthologs
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Genomic context

See GPR107 in Genome Data Viewer
Location:
9q34.11
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (130053906..130140164)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (132816185..132902443)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12063 Neighboring gene formin binding protein 1 Neighboring gene GPR107 adjacent cis regulating lncRNA Neighboring gene neuronal calcium sensor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16312, FLJ20998, FLJ22591, KIAA1624, MGC15440, MGC126118, RP11-88G17, DKFZp667C222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables clathrin heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein GPR107
Names
lung seven transmembrane receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136557.2NP_001130029.1  protein GPR107 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001130029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB046844, AL392105, BC039728, BU618007
    Consensus CDS
    CCDS48041.1
    UniProtKB/Swiss-Prot
    Q5VW38
    Related
    ENSP00000361483.1, ENST00000372406.5
    Conserved Domains (1) summary
    pfam06814
    Location:216553
    Lung_7-TM_R; Lung seven transmembrane receptor
  2. NM_001136558.2NP_001130030.1  protein GPR107 isoform 2

    See identical proteins and their annotated locations for NP_001130030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AB046844, AL136141, AL392105, BC039728, BU618007
    Consensus CDS
    CCDS48042.1
    UniProtKB/Swiss-Prot
    Q5VW38
    UniProtKB/TrEMBL
    G5E994
    Related
    ENSP00000361487.3, ENST00000372410.7
    Conserved Domains (1) summary
    pfam06814
    Location:216524
    Lung_7-TM_R; Lung seven transmembrane receptor
  3. NM_001287346.2NP_001274275.1  protein GPR107 isoform 4

    See identical proteins and their annotated locations for NP_001274275.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains multiple coding region differences and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL392105, BC030147, BC039728
    Conserved Domains (1) summary
    pfam06814
    Location:27316
    Lung_7-TM_R; Lung seven transmembrane receptor
  4. NM_020960.5NP_066011.2  protein GPR107 isoform 3

    See identical proteins and their annotated locations for NP_066011.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AB046844, BC039728, BC110518, BU618007
    Consensus CDS
    CCDS35162.1
    UniProtKB/Swiss-Prot
    Q5VW38
    Related
    ENSP00000336988.7, ENST00000347136.11
    Conserved Domains (1) summary
    pfam06814
    Location:216505
    Lung_7-TM_R; Lung seven transmembrane receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    130053906..130140164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014953.2XP_016870442.1  protein GPR107 isoform X1

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