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ZNF529 zinc finger protein 529 [ Homo sapiens (human) ]

Gene ID: 57711, updated on 12-Oct-2019

Summary

Official Symbol
ZNF529provided by HGNC
Official Full Name
zinc finger protein 529provided by HGNC
Primary source
HGNC:HGNC:29328
See related
Ensembl:ENSG00000186020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 2.5), endometrium (RPKM 2.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF529 in Genome Data Viewer
Location:
19q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36534491..36605411, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37034517..37096178, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CTBP2 pseudogene 7 Neighboring gene zinc finger protein 260 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 461 Neighboring gene zinc finger protein 567 Neighboring gene long intergenic non-protein coding RNA 1534

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145649.2NP_001139121.1  zinc finger protein 529 isoform a

    See identical proteins and their annotated locations for NP_001139121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC092295, BC036578, BP279443, DA111996
    Consensus CDS
    CCDS54256.1
    UniProtKB/Swiss-Prot
    Q6P280
    Conserved Domains (5) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:408431
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001145650.2NP_001139122.1  zinc finger protein 529 isoform b

    See identical proteins and their annotated locations for NP_001139122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC092295, BC036578, DA503147
    Conserved Domains (5) summary
    smart00349
    Location:2163
    KRAB; krueppel associated box
    COG5048
    Location:374526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2160
    KRAB; KRAB box
    pfam13465
    Location:390413
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001321351.2NP_001308280.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/Swiss-Prot
    Q6P280
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Related
    ENSP00000334695.7, ENST00000334116.7
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001352272.2NP_001339201.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001352273.2NP_001339202.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_020951.5NP_066002.3  zinc finger protein 529 isoform a

    See identical proteins and their annotated locations for NP_066002.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC092295, BC036578, BC064690, BX503547
    Consensus CDS
    CCDS54256.1
    UniProtKB/Swiss-Prot
    Q6P280
    Related
    ENSP00000465578.1, ENST00000591340.6
    Conserved Domains (5) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:408431
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_027239.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 3' exons but includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, as found in variant 1.
    Source sequence(s)
    AK091072, AK094618, AL109722, DA111996
    Related
    ENST00000586458.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36534491..36605411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527169.2XP_011525471.1  zinc finger protein 529 isoform X5

    Conserved Domains (5) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:336396
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:325347
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011527170.1XP_011525472.1  zinc finger protein 529 isoform X7

    Conserved Domains (6) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:336391
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:325347
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027039.1XP_016882528.1  zinc finger protein 529 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:2163
    KRAB; krueppel associated box
    COG5048
    Location:374526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2160
    KRAB; KRAB box
    pfam13465
    Location:390413
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017027042.1XP_016882531.1  zinc finger protein 529 isoform X4

    UniProtKB/Swiss-Prot
    Q6P280
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_017027043.1XP_016882532.1  zinc finger protein 529 isoform X4

    UniProtKB/Swiss-Prot
    Q6P280
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_017027040.1XP_016882529.1  zinc finger protein 529 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:323475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:339362
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011527166.2XP_011525468.1  zinc finger protein 529 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:323475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:383403
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:339362
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011527165.3XP_011525467.1  zinc finger protein 529 isoform X2

    See identical proteins and their annotated locations for XP_011525467.1

    Conserved Domains (5) summary
    smart00349
    Location:2163
    KRAB; krueppel associated box
    COG5048
    Location:374526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2160
    KRAB; KRAB box
    pfam13465
    Location:390413
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011527164.3XP_011525466.1  zinc finger protein 529 isoform X1

    See identical proteins and their annotated locations for XP_011525466.1

    UniProtKB/Swiss-Prot
    Q6P280
    Conserved Domains (5) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:408431
    zf-H2C2_2; Zinc-finger double domain
  10. XM_006723302.4XP_006723365.1  zinc finger protein 529 isoform X1

    See identical proteins and their annotated locations for XP_006723365.1

    UniProtKB/Swiss-Prot
    Q6P280
    Conserved Domains (5) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:408431
    zf-H2C2_2; Zinc-finger double domain
  11. XM_006723304.3XP_006723367.1  zinc finger protein 529 isoform X6

    Conserved Domains (6) summary
    smart00349
    Location:3981
    KRAB; krueppel associated box
    COG5048
    Location:336397
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:282304
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3978
    KRAB; KRAB box
    pfam13465
    Location:325347
    zf-H2C2_2; Zinc-finger double domain
  12. XM_017027045.2XP_016882534.1  zinc finger protein 529 isoform X8

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