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ZNF529 zinc finger protein 529 [ Homo sapiens (human) ]

Gene ID: 57711, updated on 6-Sep-2022

Summary

Official Symbol
ZNF529provided by HGNC
Official Full Name
zinc finger protein 529provided by HGNC
Primary source
HGNC:HGNC:29328
See related
Ensembl:ENSG00000186020 AllianceGenome:HGNC:29328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.5), endometrium (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF529 in Genome Data Viewer
Location:
19q13.12
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36543613..36605543, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39218884..39280542, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37034515..37096159, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CTBP2 pseudogene 7 Neighboring gene zinc finger protein 260 Neighboring gene ZNF529 antisense RNA 1 Neighboring gene zinc finger protein 382 Neighboring gene zinc finger protein 461 Neighboring gene zinc finger protein 567 Neighboring gene ZNF567 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1615

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145649.2NP_001139121.1  zinc finger protein 529 isoform a

    See identical proteins and their annotated locations for NP_001139121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC092295, BC036578, BP279443, DA111996
    Consensus CDS
    CCDS54256.1
    UniProtKB/Swiss-Prot
    Q6P280, Q9HCF7
    Conserved Domains (3) summary
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3879
    KRAB; KRAB box
  2. NM_001145650.2NP_001139122.1  zinc finger protein 529 isoform b

    See identical proteins and their annotated locations for NP_001139122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC092295, BC036578, DA503147
    Conserved Domains (3) summary
    COG5048
    Location:374526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2061
    KRAB; KRAB box
  3. NM_001321351.2NP_001308280.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/Swiss-Prot
    Q6P280
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Related
    ENSP00000334695.7, ENST00000334116.7
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001352272.2NP_001339201.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001352273.2NP_001339202.1  zinc finger protein 529 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC092295, AK025110, BX503547
    Consensus CDS
    CCDS82335.1
    UniProtKB/TrEMBL
    A0A0C4DFR4
    Conserved Domains (2) summary
    COG5048
    Location:287439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:347367
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_020951.5NP_066002.3  zinc finger protein 529 isoform a

    See identical proteins and their annotated locations for NP_066002.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC092295, BC036578, BC064690, BX503547
    Consensus CDS
    CCDS54256.1
    UniProtKB/Swiss-Prot
    Q6P280, Q9HCF7
    Related
    ENSP00000465578.1, ENST00000591340.6
    Conserved Domains (3) summary
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3879
    KRAB; KRAB box

RNA

  1. NR_027239.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several 3' exons but includes an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the coding region, as found in variant 1.
    Source sequence(s)
    AK091072, AK094618, AL109722, DA111996
    Related
    ENST00000586458.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36543613..36605543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527164.4XP_011525466.1  zinc finger protein 529 isoform X1

    See identical proteins and their annotated locations for XP_011525466.1

    UniProtKB/Swiss-Prot
    Q6P280, Q9HCF7
    Conserved Domains (3) summary
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3879
    KRAB; KRAB box
  2. XM_011527165.4XP_011525467.1  zinc finger protein 529 isoform X2

    See identical proteins and their annotated locations for XP_011525467.1

    Conserved Domains (3) summary
    COG5048
    Location:374526
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2061
    KRAB; KRAB box
  3. XM_006723302.5XP_006723365.1  zinc finger protein 529 isoform X1

    See identical proteins and their annotated locations for XP_006723365.1

    UniProtKB/Swiss-Prot
    Q6P280, Q9HCF7
    Conserved Domains (3) summary
    COG5048
    Location:392544
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452472
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3879
    KRAB; KRAB box
  4. XM_047439141.1XP_047295097.1  zinc finger protein 529 isoform X4

    UniProtKB/TrEMBL
    A0A0C4DFR4
  5. XM_047439140.1XP_047295096.1  zinc finger protein 529 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39218884..39280542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)