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KIAA1614 KIAA1614 [ Homo sapiens (human) ]

Gene ID: 57710, updated on 10-Oct-2024

Summary

Official Symbol
KIAA1614provided by HGNC
Official Full Name
KIAA1614provided by HGNC
Primary source
HGNC:HGNC:29327
See related
Ensembl:ENSG00000135835 AllianceGenome:HGNC:29327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein kinase C binding activity. Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.6), ovary (RPKM 1.5) and 22 other tissues See more
Orthologs
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Genomic context

See KIAA1614 in Genome Data Viewer
Location:
1q25.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (180912897..180951614)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (180268104..180306855)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (180882033..180920750)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene xenotropic and polytropic retrovirus receptor 1 Neighboring gene uncharacterized LOC124904687 Neighboring gene MPRA-validated peak488 silencer Neighboring gene MPRA-validated peak489 silencer Neighboring gene uncharacterized LOC124904464 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:180866978-180867370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180868044-180868872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2165 Neighboring gene long intergenic non-protein coding RNA 2816 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180892213-180893094 Neighboring gene uncharacterized LOC107985231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180910063-180911042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180918561-180919111 Neighboring gene KIAA1614 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:180923653-180924258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1598 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:180959945-180960105 Neighboring gene MPRA-validated peak491 silencer Neighboring gene major histocompatibility complex, class I-related pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:180991746-180992529 Neighboring gene syntaxin 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: XPR1

Clone Names

  • FLJ32095

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment or maintenance of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cellular localization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
uncharacterized protein KIAA1614

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427641.1NP_001414570.1  uncharacterized protein KIAA1614 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL162431
    UniProtKB/TrEMBL
    A0AAQ5BGH9
  2. NM_020950.2NP_066001.1  uncharacterized protein KIAA1614 isoform 2

    See identical proteins and their annotated locations for NP_066001.1

    Status: VALIDATED

    Source sequence(s)
    AB046834, AL162431, DA410555, DA807788
    Consensus CDS
    CCDS41442.1
    UniProtKB/Swiss-Prot
    Q5VZ45, Q5VZ46, Q9HCF8
    Related
    ENSP00000356560.4, ENST00000367588.9
    Conserved Domains (1) summary
    pfam15737
    Location:354478
    DUF4685; Domain of unknown function (DUF4685)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    180912897..180951614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    180268104..180306855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)