PTPN2 protein tyrosine phosphatase non-receptor type 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTPN2provided by HGNC
Official Full Name: protein tyrosine phosphatase non-receptor type 2provided by HGNC
Primary source: HGNC:HGNC:9650
See related: Ensembl:ENSG00000175354 MIM:176887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Expression: Ubiquitous expression in appendix (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 18p11.21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109.20191205	current	GRCh38.p13 (GCF_000001405.39)	18	NC_000018.10 (12785478..12884351, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (12785477..12884337, complement)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Low PTPN2 protein expression was found in 50.2% of the breast tumours (110/219), gene copy loss in 15.4% (33/214). Low protein expression was associated with a higher relapse rate in patients with Luminal A and HER2-positive tumours, but not triple-negative tumours.
Title: The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype.
A dual role for myeloid PTPN2 in directly regulating inflammasome activation and IL-1beta production to suppress pro-inflammatory responses during colitis but promote intestinal tumor development, is reported.
Title: PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Further comparison of alanine scanning demonstrates that the reduction in the energy contribution of Arg254 caused by A27S mutation leads to a different inhibitory activity. These observations provide novel insights into the selective binding mechanism of PTP1B inhibitors to TCPTP
Title: Molecular Dynamics Simulations of A27S and K120A Mutated PTP1B Reveals Selective Binding of the Bidentate Inhibitor.
The higher levels of PTPN2 were associated with a worse overall survival both in patients with gliomas and glioblastomas.
Title: Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas.
This study shows that a PTPN2-rs7234029 polymorphism is associated with ocular Behcet's disease and is strongly influenced by gender. In addition, our results suggest that the genetic association with PTPN2 may involve the regulation of PTPN2 mRNA expression and cytokine secretion.
Title: Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease.
PTPN2 negatively regulates Akt signalling and loss of PTPN2 protein along with increased pAkt-n is a new potential clinical marker of endocrine treatment efficacy in breast cancer
Title: PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer.
RA samples with PTPN2:rs478582 and/or PTPN22:rs2476601 were more positive for MAP than samples without polymorphisms. Combined occurrence of PTPN2:rs478582 and PTPN22:rs2476601 in association with the presence of MAP has significantly increased T-cell response and elevated IFN-gamma expression in RA samples.
Title: Polymorphisms in <i>Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22)</i> Are Linked to Hyper-Proliferative T-Cells and Susceptibility to <i>Mycobacteria</i> in Rheumatoid Arthritis.
our data indicate a novel role for PTPN2 and PTPN22 in controlling intestinal microbiota composition and further elucidate the complex interplay between genetic risk factors, intestinal microbiota and disease course in IBD patients.
Title: The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.
The results provide the first indication that PTPN2 variants contribute to the risk of Type 1A diabetes, and possibly induce non-specific Type 1A diabetes.
Title: Protein-altering variants of PTPN2 in childhood-onset Type 1A diabetes.
PTPN2, an anti-inflammatory factor regulated by VDR, was reduced in type 2 diabetics with chronic kidney disease stages 1-2.
Title: PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Multiple common variants for celiac disease influencing immune gene expression. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC31554 (e-PCR)
- UniSTS:76564

RH65175 (e-PCR)
- UniSTS:89633

sY3084 (e-PCR)
- UniSTS:515126

GDB:217060 (e-PCR)
- UniSTS:156225

STS-N53696 (e-PCR)
- UniSTS:76658

D1S1425 (e-PCR)
- UniSTS:149621

RH36905 (e-PCR)
- UniSTS:87932

RH12560 (e-PCR)
- UniSTS:84170

GDB:196599 (e-PCR)
- UniSTS:155871

ECD04345 (e-PCR)
- UniSTS:285422

STS-M78585 (e-PCR)
- UniSTS:42996

Homology

Homologs of the PTPN2 gene: The PTPN2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 270 organisms have orthologs with human gene PTPN2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
STAT family protein binding	IEA Inferred from Electronic Annotation more info
integrin binding	IPI Inferred from Physical Interaction more info	PubMed
non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine phosphatase activity	EXP Inferred from Experiment more info	PubMed
protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
cellular response to cytokine stimulus	TAS Traceable Author Statement more info
erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interferon-gamma-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-2-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-4-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of macrophage colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of platelet-derived growth factor receptor-beta signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of positive thymic T cell selection	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
negative regulation of tumor necrosis factor-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of tyrosine phosphorylation of STAT protein	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-tyrosine dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of PERK-mediated unfolded protein response	IEA Inferred from Electronic Annotation more info
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
regulation of hepatocyte growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 2

Names: T-cell protein tyrosine phosphatase

NP_001193942.1

EC 3.1.3.48

NP_001295216.1

EC 3.1.3.48

NP_002819.2

EC 3.1.3.48

NP_536347.1

EC 3.1.3.48

NP_536348.1

EC 3.1.3.48

XP_005258181.1

EC 3.1.3.48

XP_005258182.1

EC 3.1.3.48

XP_011524007.1

EC 3.1.3.48

XP_011524008.1

EC 3.1.3.48

XP_011524009.1

EC 3.1.3.48

XP_016881373.1

EC 3.1.3.48

XP_016881374.1

EC 3.1.3.48

XP_016881375.1

EC 3.1.3.48

XP_016881376.1

EC 3.1.3.48

XP_016881377.1

EC 3.1.3.48

XP_024306996.1

EC 3.1.3.48

XP_024306997.1

EC 3.1.3.48

XP_024306998.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029116.1 RefSeqGene

Range

5001..103858

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001207013.1 → NP_001193942.1 tyrosine-protein phosphatase non-receptor type 2 isoform 4

See identical proteins and their annotated locations for NP_001193942.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an additional in-frame exon in the middle coding region and an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (4) has an additional internal segment and a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AK225706, BG699440, BQ010946

Consensus CDS

CCDS59306.1

UniProtKB/Swiss-Prot

P17706

Related

ENSP00000466936.1, ENST00000591115.5

Conserved Domains (2) summary

cd00047
Location:45 → 297

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:42 → 297

Y_phosphatase; Protein-tyrosine phosphatase
NM_001308287.1 → NP_001295216.1 tyrosine-protein phosphatase non-receptor type 2 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from an alternate start codon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus, as compared to isoform 1.

Source sequence(s)

AB209569, AP001077

Consensus CDS

CCDS77155.1

UniProtKB/TrEMBL

K7EQG9, Q59F91

Related

ENSP00000467823.1, ENST00000591497.5

Conserved Domains (2) summary

cd00047
Location:26 → 245

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:26 → 245

Y_phosphatase; Protein-tyrosine phosphatase
NM_002828.4 → NP_002819.2 tyrosine-protein phosphatase non-receptor type 2 isoform 1

See identical proteins and their annotated locations for NP_002819.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AB209569, AK292570, AP001077, BG699440, DB350067

Consensus CDS

CCDS11865.1

UniProtKB/Swiss-Prot

P17706

UniProtKB/TrEMBL

Q59F91

Related

ENSP00000311857.3, ENST00000309660.10

Conserved Domains (2) summary

smart00194
Location:5 → 274

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:45 → 274

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_080422.2 → NP_536347.1 tyrosine-protein phosphatase non-receptor type 2 isoform 2

See identical proteins and their annotated locations for NP_536347.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AK290649, BG699440, BQ010946

Consensus CDS

CCDS11863.1

UniProtKB/Swiss-Prot

P17706

UniProtKB/TrEMBL

A8K3N4

Related

ENSP00000320298.3, ENST00000327283.7

Conserved Domains (1) summary

pfam00102
Location:42 → 274

Y_phosphatase; Protein-tyrosine phosphatase
NM_080423.2 → NP_536348.1 tyrosine-protein phosphatase non-receptor type 2 isoform 3

See identical proteins and their annotated locations for NP_536348.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 3' region, which includes a part of the C-terminal coding region, when compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.

Source sequence(s)

BC016727, BG699440, BQ010946

Consensus CDS

CCDS11864.1

UniProtKB/Swiss-Prot

P17706

Related

ENSP00000320546.3, ENST00000353319.8

Conserved Domains (2) summary

smart00194
Location:5 → 274

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:45 → 274

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000018.10 Reference GRCh38.p13 Primary Assembly

Range

12785478..12884351 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005258125.4 → XP_005258182.1 tyrosine-protein phosphatase non-receptor type 2 isoform X2

Conserved Domains (2) summary

cd00047
Location:45 → 297

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:42 → 297

Y_phosphatase; Protein-tyrosine phosphatase
XM_017025888.2 → XP_016881377.1 tyrosine-protein phosphatase non-receptor type 2 isoform X10

Conserved Domains (2) summary

cd00047
Location:1 → 175

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:1 → 175

Y_phosphatase; Protein-tyrosine phosphatase
XM_024451228.1 → XP_024306996.1 tyrosine-protein phosphatase non-receptor type 2 isoform X7

Conserved Domains (1) summary

pfam00102
Location:42 → 229

Y_phosphatase; Protein-tyrosine phosphatase
XM_017025884.1 → XP_016881373.1 tyrosine-protein phosphatase non-receptor type 2 isoform X4
XM_017025887.2 → XP_016881376.1 tyrosine-protein phosphatase non-receptor type 2 isoform X9
XM_005258124.4 → XP_005258181.1 tyrosine-protein phosphatase non-receptor type 2 isoform X1

Conserved Domains (2) summary

cd00047
Location:45 → 297

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:42 → 297

Y_phosphatase; Protein-tyrosine phosphatase
XM_017025886.1 → XP_016881375.1 tyrosine-protein phosphatase non-receptor type 2 isoform X8

UniProtKB/TrEMBL

D3DUJ3

Conserved Domains (1) summary

cd00047
Location:1 → 175

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_011525706.2 → XP_011524008.1 tyrosine-protein phosphatase non-receptor type 2 isoform X6

Conserved Domains (2) summary

cd00047
Location:45 → 229

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:42 → 229

Y_phosphatase; Protein-tyrosine phosphatase
XM_011525705.3 → XP_011524007.1 tyrosine-protein phosphatase non-receptor type 2 isoform X3

Conserved Domains (2) summary

cd00047
Location:26 → 268

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:26 → 268

Y_phosphatase; Protein-tyrosine phosphatase
XM_017025885.2 → XP_016881374.1 tyrosine-protein phosphatase non-receptor type 2 isoform X5

UniProtKB/TrEMBL

K7EQG9

Conserved Domains (2) summary

cd00047
Location:26 → 245

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:26 → 245

Y_phosphatase; Protein-tyrosine phosphatase
XM_024451229.1 → XP_024306997.1 tyrosine-protein phosphatase non-receptor type 2 isoform X8

Related

ENSP00000493693.1, ENST00000645191.1

Conserved Domains (1) summary

cd00047
Location:1 → 175

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_024451230.1 → XP_024306998.1 tyrosine-protein phosphatase non-receptor type 2 isoform X8

Related

ENSP00000496181.1, ENST00000646492.1

Conserved Domains (1) summary

cd00047
Location:1 → 175

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_011525707.2 → XP_011524009.1 tyrosine-protein phosphatase non-receptor type 2 isoform X11

Conserved Domains (2) summary

cd00047
Location:8 → 118

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:9 → 118

Y_phosphatase; Protein-tyrosine phosphatase