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MEAK7 MTOR associated protein, eak-7 homolog [ Homo sapiens (human) ]

Gene ID: 57707, updated on 6-Nov-2022

Summary

Official Symbol
MEAK7provided by HGNC
Official Full Name
MTOR associated protein, eak-7 homologprovided by HGNC
Primary source
HGNC:HGNC:29325
See related
Ensembl:ENSG00000140950 MIM:619331; AllianceGenome:HGNC:29325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAK7; TLDC1; mEAK-7; KIAA1609
Summary
Involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Located in cytosol; lysosomal membrane; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 6.1), esophagus (RPKM 5.1) and 23 other tissues See more
Orthologs
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Genomic context

See MEAK7 in Genome Data Viewer
Location:
16q24.1
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (84476355..84504659, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (90542752..90570998, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (84509961..84538265, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 1 Neighboring gene ATPase secretory pathway Ca2+ transporting 2 Neighboring gene ATP2C2 antisense RNA 1 Neighboring gene uncharacterized LOC124903736 Neighboring gene uncharacterized LOC124903735

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1609, MGC25024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in lysosomal membrane HDA PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MTOR-associated protein MEAK7
Names
TBC/LysM-associated domain containing 1
TBC/LysM-associated domain-containing protein 1
TLD domain containing 1
TLD domain-containing protein 1
mammalian EAK-7
NP_065998.3
XP_005256132.1
XP_016879000.1
XP_047290366.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020947.4NP_065998.3  MTOR-associated protein MEAK7

    See identical proteins and their annotated locations for NP_065998.3

    Status: VALIDATED

    Source sequence(s)
    AC022165, AK291237, AK310887
    Consensus CDS
    CCDS32498.1
    UniProtKB/Swiss-Prot
    Q6P9B6, Q9NTE8
    UniProtKB/TrEMBL
    A8K5C2
    Related
    ENSP00000343635.6, ENST00000343629.11
    Conserved Domains (1) summary
    smart00584
    Location:244412
    TLDc; domain in TBC and LysM domain containing proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    84476355..84504659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256075.3XP_005256132.1  MTOR-associated protein MEAK7 isoform X1

    See identical proteins and their annotated locations for XP_005256132.1

    UniProtKB/Swiss-Prot
    Q6P9B6, Q9NTE8
    Conserved Domains (1) summary
    smart00584
    Location:244412
    TLDc; domain in TBC and LysM domain containing proteins
  2. XM_017023511.2XP_016879000.1  MTOR-associated protein MEAK7 isoform X1

    UniProtKB/Swiss-Prot
    Q6P9B6, Q9NTE8
    Conserved Domains (1) summary
    smart00584
    Location:244412
    TLDc; domain in TBC and LysM domain containing proteins
  3. XM_047434410.1XP_047290366.1  MTOR-associated protein MEAK7 isoform X1

    UniProtKB/Swiss-Prot
    Q9NTE8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    90542752..90570998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)