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CWC22 CWC22 spliceosome associated protein homolog [ Homo sapiens (human) ]

Gene ID: 57703, updated on 3-Jun-2018
Official Symbol
CWC22provided by HGNC
Official Full Name
CWC22 spliceosome associated protein homologprovided by HGNC
Primary source
HGNC:HGNC:29322
See related
Ensembl:ENSG00000163510 MIM:615186; Vega:OTTHUMG00000154244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCM; fSAPb; EIF4GL
Expression
Ubiquitous expression in lymph node (RPKM 9.1), thyroid (RPKM 8.8) and 25 other tissues See more
Orthologs
See CWC22 in Genome Data Viewer
Location:
2q31.3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (179944876..180007296, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (180809603..180872024, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385B Neighboring gene thioredoxin like 4A pseudogene Neighboring gene microRNA 1258 Neighboring gene uncharacterized LOC105373767 Neighboring gene uncharacterized LOC105373768

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
    Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
  • mRNA Splicing, organism-specific biosystem (from REACTOME)
    mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
  • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
    mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1604

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
mRNA splicing, via spliceosome TAS
Traceable Author Statement
more info
 
regulation of mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
U2-type catalytic step 1 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
pre-mRNA-splicing factor CWC22 homolog
Names
CWC22 homolog, spliceosome-associated protein
CWC22 spliceosome-associated protein
functional spliceosome-associated protein b
nucampholin homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020943.2NP_065994.1  pre-mRNA-splicing factor CWC22 homolog

    See identical proteins and their annotated locations for NP_065994.1

    Status: VALIDATED

    Source sequence(s)
    AB046824, BC031216
    Consensus CDS
    CCDS46465.1
    UniProtKB/Swiss-Prot
    Q9HCG8
    Related
    ENSP00000387006.3, OTTHUMP00000205374, ENST00000410053.7, OTTHUMT00000334537
    Conserved Domains (3) summary
    smart00543
    Location:164345
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02847
    Location:455561
    MA3; MA3 domain
    cl25887
    Location:821902
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    179944876..180007296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246726.3XP_005246783.1  pre-mRNA-splicing factor CWC22 homolog isoform X1

    See identical proteins and their annotated locations for XP_005246783.1

    UniProtKB/Swiss-Prot
    Q9HCG8
    Related
    ENSP00000384159.2, OTTHUMP00000205375, ENST00000404136.2
    Conserved Domains (3) summary
    smart00543
    Location:164345
    MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
    pfam02847
    Location:455561
    MA3; MA3 domain
    cl25887
    Location:821902
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
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