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ADGRB3 adhesion G protein-coupled receptor B3 [ Homo sapiens (human) ]

Gene ID: 577, updated on 6-Jul-2025
Official Symbol
ADGRB3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B3provided by HGNC
Primary source
HGNC:HGNC:945
See related
Ensembl:ENSG00000135298 MIM:602684; AllianceGenome:HGNC:945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI3
Summary
This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.6), adrenal (RPKM 0.8) and 3 other tissues See more
Orthologs
NEW
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See ADGRB3 in Genome Data Viewer
Location:
6q12-q13
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (68635282..69389506)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (69812849..70568164)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (69345174..70099398)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2549 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:69073362-69073543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17313 Neighboring gene uncharacterized LOC127898563 Neighboring gene NANOG hESC enhancer GRCh37_chr6:69359553-69360054 Neighboring gene Sharpr-MPRA regulatory region 12523 Neighboring gene uncharacterized LOC124901511 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:69404211-69404763 Neighboring gene ADGRB3 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 12937 Neighboring gene uncharacterized LOC124901492 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_94316 Neighboring gene Sharpr-MPRA regulatory region 12106 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:69890327-69891526 Neighboring gene Sharpr-MPRA regulatory region 1724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:69925706-69926680 Neighboring gene Sharpr-MPRA regulatory region 3236 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:70118423-70119622 Neighboring gene NANOG hESC enhancer GRCh37_chr6:70141628-70142137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:70154657-70155166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:70155167-70155674 Neighboring gene Sharpr-MPRA regulatory region 1352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24725 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:70364977-70365478 Neighboring gene MPRA-validated peak5886 silencer Neighboring gene uncharacterized LOC124901337 Neighboring gene LMBR1 domain containing 1 Neighboring gene nucleophosmin 1 pseudogene 37 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 42

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA0550, MGC133100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within maintenance of synapse structure IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within motor learning IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast fusion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synapse maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synapse pruning IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic cleft IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic cleft IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adhesion G protein-coupled receptor B3
Names
brain-specific angiogenesis inhibitor 3
dJ91B17.1 (brain-specific angiogenesis inhibitor 3)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001704.3NP_001695.2  adhesion G protein-coupled receptor B3

    Status: REVIEWED

    Source sequence(s)
    AL133378, AL158051, AL160401, AL356117, AL359714, AL391807, KF458189
    Consensus CDS
    CCDS4968.1
    UniProtKB/Swiss-Prot
    B7Z1K0, O60242, O60297, Q2NKN6, Q5VY37, Q9BX54
    UniProtKB/TrEMBL
    A8K0Y1
    Related
    ENSP00000359630.1, ENST00000370598.6
    Conserved Domains (6) summary
    smart00303
    Location:816867
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:510576
    HormR; Domain present in hormone receptors
    smart00209
    Location:348398
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:594794
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15989
    Location:8721164
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl25971
    Location:98175
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    68635282..69389506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    69812849..70568164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)