Format

Send to:

Choose Destination

ADGRB3 adhesion G protein-coupled receptor B3 [ Homo sapiens (human) ]

Gene ID: 577, updated on 12-Oct-2019

Summary

Official Symbol
ADGRB3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B3provided by HGNC
Primary source
HGNC:HGNC:945
See related
Ensembl:ENSG00000135298 MIM:602684
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI3
Summary
This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 7.6), adrenal (RPKM 0.8) and 3 other tissues See more
Orthologs

Genomic context

See ADGRB3 in Genome Data Viewer
Location:
6q12-q13
Exon count:
32
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (68635282..69389506)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (69345210..70099403)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2549 Neighboring gene uncharacterized LOC101928307 Neighboring gene Sharpr-MPRA regulatory region 12937 Neighboring gene Sharpr-MPRA regulatory region 3236 Neighboring gene LMBR1 domain containing 1 Neighboring gene nucleophosmin 1 pseudogene 37 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0550, MGC133100

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
maintenance of synapse structure IEA
Inferred from Electronic Annotation
more info
 
motor learning IEA
Inferred from Electronic Annotation
more info
 
myoblast fusion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
neuron remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IPI
Inferred from Physical Interaction
more info
PubMed 
postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic cleft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor B3
Names
brain-specific angiogenesis inhibitor 3
dJ91B17.1 (brain-specific angiogenesis inhibitor 3)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001704.3NP_001695.2  adhesion G protein-coupled receptor B3

    Status: REVIEWED

    Source sequence(s)
    AL133378, AL158051, AL160401, AL356117, AL359714, AL391807, KF458189
    Consensus CDS
    CCDS4968.1
    Related
    ENSP00000359630.1, ENST00000370598.6
    Conserved Domains (6) summary
    smart00303
    Location:816867
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:510576
    HormR; Domain present in hormone receptors
    smart00209
    Location:348398
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:594794
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15989
    Location:8721164
    7tmB2_BAI3; brain-specific angiogenesis inhibitor 3, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    cl25971
    Location:98175
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    68635282..69389506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center