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USP37 ubiquitin specific peptidase 37 [ Homo sapiens (human) ]

Gene ID: 57695, updated on 11-Sep-2019

Summary

Official Symbol
USP37provided by HGNC
Official Full Name
ubiquitin specific peptidase 37provided by HGNC
Primary source
HGNC:HGNC:20063
See related
Ensembl:ENSG00000135913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 8.0), small intestine (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See USP37 in Genome Data Viewer
Location:
2q35
Exon count:
27
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218450251..218568393, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219314974..219433084, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 1 Neighboring gene CTD small phosphatase 1 Neighboring gene microRNA 26b Neighboring gene villin 1 Neighboring gene RN7SK pseudogene 38 Neighboring gene CCR4-NOT transcription complex subunit 9 Neighboring gene RNA, U6 small nuclear 136, pseudogene Neighboring gene tRNA-Gln (anticodon CTG) 16-1 Neighboring gene phospholipase C delta 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1594, MGC117261

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitinyl hydrolase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K48-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 37
Names
deubiquitinating enzyme 37
tmp_locus_50
ubiquitin specific protease 37
ubiquitin thioesterase 37
ubiquitin thiolesterase 37
ubiquitin-specific-processing protease 37
NP_065986.3
XP_005246777.1
XP_005246778.1
XP_005246779.1
XP_005246781.1
XP_011509840.1
XP_011509843.1
XP_016860066.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020935.3NP_065986.3  ubiquitin carboxyl-terminal hydrolase 37

    Status: VALIDATED

    Source sequence(s)
    AC012510, AC073838
    Consensus CDS
    CCDS2418.1
    Related
    ENSP00000258399.3, ENST00000258399.8
    Conserved Domains (3) summary
    cd02257
    Location:881949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218450251..218568393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246720.3XP_005246777.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_005246777.1

    UniProtKB/Swiss-Prot
    Q86T82
    Related
    ENSP00000393662.1, ENST00000454775.5
    Conserved Domains (3) summary
    cd02257
    Location:881949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
  2. XM_005246721.4XP_005246778.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_005246778.1

    UniProtKB/Swiss-Prot
    Q86T82
    Related
    ENSP00000396585.1, ENST00000418019.5
    Conserved Domains (3) summary
    cd02257
    Location:881949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
  3. XM_005246722.4XP_005246779.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_005246779.1

    UniProtKB/Swiss-Prot
    Q86T82
    Conserved Domains (3) summary
    cd02257
    Location:881949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
  4. XM_011511538.3XP_011509840.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X1

    See identical proteins and their annotated locations for XP_011509840.1

    UniProtKB/Swiss-Prot
    Q86T82
    Conserved Domains (3) summary
    cd02257
    Location:881949
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342601
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
  5. XM_005246724.2XP_005246781.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X2

    Related
    ENSP00000400902.1, ENST00000415516.5
    Conserved Domains (4) summary
    cd02257
    Location:342603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:342449
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
  6. XM_017004577.2XP_016860066.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X3

    Conserved Domains (3) summary
    cd02257
    Location:94355
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:94201
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:94352
    UCH; Ubiquitin carboxyl-terminal hydrolase
  7. XM_011511541.2XP_011509843.1  ubiquitin carboxyl-terminal hydrolase 37 isoform X4

    Conserved Domains (4) summary
    cd02257
    Location:342603
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:342449
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:342600
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
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