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MAGEE1 MAGE family member E1 [ Homo sapiens (human) ]

Gene ID: 57692, updated on 8-Jul-2018
Official Symbol
MAGEE1provided by HGNC
Official Full Name
MAGE family member E1provided by HGNC
Primary source
HGNC:HGNC:24934
See related
Ensembl:ENSG00000198934 MIM:300759; Vega:OTTHUMG00000021879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA1; DAMAGE
Summary
This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]
Orthologs
See MAGEE1 in Genome Data Viewer
Location:
Xq13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (76427653..76431353)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (75648046..75651746)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group FRD member 1 pseudogene Neighboring gene lactate dehydrogenase B pseudogene 2 Neighboring gene trafficking protein particle complex 13 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 508

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of melanoma antigen family E, 1 (MAGEE1) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with dystrophin-associated glycoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
melanoma-associated antigen E1
Names
MAGE-E1 antigen
alpha-dystrobrevin-associated MAGE Protein
dystrobrevin-associated MAGE protein
hepatocellular carcinoma-associated HCA1
hepatocellular carcinoma-associated protein 1
melanoma antigen family E, 1
melanoma antigen family E1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016774.1 RefSeqGene

    Range
    5001..8701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020932.2NP_065983.1  melanoma-associated antigen E1

    See identical proteins and their annotated locations for NP_065983.1

    Status: REVIEWED

    Source sequence(s)
    AB046807, BC050588, DA411859
    Consensus CDS
    CCDS14433.1
    UniProtKB/Swiss-Prot
    Q9HCI5
    Related
    ENSP00000354912.2, OTTHUMP00000023588, ENST00000361470.3, OTTHUMT00000057298
    Conserved Domains (2) summary
    pfam01454
    Location:498666
    MAGE; MAGE family
    pfam06752
    Location:143266
    E_Pc_C; Enhancer of Polycomb C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    76427653..76431353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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