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KIAA1586 KIAA1586 [ Homo sapiens (human) ]

Gene ID: 57691, updated on 12-Oct-2019

Summary

Official Symbol
KIAA1586provided by HGNC
Official Full Name
KIAA1586provided by HGNC
Primary source
HGNC:HGNC:21360
See related
Ensembl:ENSG00000168116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 5.5), placenta (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See KIAA1586 in Genome Data Viewer
Location:
6p12.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (57046532..57055739)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (56911343..56920023)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene BEN domain containing 6 Neighboring gene ferritin heavy chain 1 pseudogene 15 Neighboring gene mitochondrial ribosomal protein L30 pseudogene 1 Neighboring gene zinc finger protein 451 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene BAG cochaperone 2 Neighboring gene RAB23, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 SUMO-protein ligase KIAA1586

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286274.1NP_001273203.1  E3 SUMO-protein ligase KIAA1586 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK295519, BC041125, CN359914, DC407946
    Consensus CDS
    CCDS69138.1
    UniProtKB/Swiss-Prot
    Q9HCI6
    UniProtKB/TrEMBL
    B4DIC2, F5H2N6
    Related
    ENSP00000445507.1, ENST00000545356.5
  2. NM_001286275.1NP_001273204.1  E3 SUMO-protein ligase KIAA1586 isoform c

    See identical proteins and their annotated locations for NP_001273204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    BC041125, BG028983, CN359914, DC407946
    UniProtKB/Swiss-Prot
    Q9HCI6
  3. NM_001286276.1NP_001273205.1  E3 SUMO-protein ligase KIAA1586 isoform c

    See identical proteins and their annotated locations for NP_001273205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AL450489, BC041125, BF699031, CN359914
    UniProtKB/Swiss-Prot
    Q9HCI6
  4. NM_020931.4NP_065982.1  E3 SUMO-protein ligase KIAA1586 isoform a

    See identical proteins and their annotated locations for NP_065982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC041125, CN359914
    Consensus CDS
    CCDS34480.1
    UniProtKB/Swiss-Prot
    Q9HCI6
    Related
    ENSP00000359768.4, ENST00000370733.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    57046532..57055739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514767.2XP_011513069.1  E3 SUMO-protein ligase KIAA1586 isoform X1

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