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LRRC4C leucine rich repeat containing 4C [ Homo sapiens (human) ]

Gene ID: 57689, updated on 23-Nov-2023

Summary

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Official Symbol
LRRC4Cprovided by HGNC
Official Full Name
leucine rich repeat containing 4Cprovided by HGNC
Primary source
HGNC:HGNC:29317
See related
Ensembl:ENSG00000148948 MIM:608817; AllianceGenome:HGNC:29317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGL1; NGL-1
Summary
NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 5.3), adrenal (RPKM 0.7) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See LRRC4C in Genome Data Viewer
Location:
11p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (40114199..41459652, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (40260753..41606210, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (40135749..41481202, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376637 Neighboring gene adaptor related protein complex 5 subunit mu 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:39902599-39903100 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40005787-40006001 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40052323-40052873 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121095-40121596 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:40121597-40122096 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:40173418-40174617 Neighboring gene zinc finger CCHC-type containing 9 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40224036-40224631 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:40225695-40226477 Neighboring gene NANOG hESC enhancer GRCh37_chr11:40248664-40249165 Neighboring gene zinc finger protein 12 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:40669848-40671047 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:40700680-40701265 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:40816984-40817169 Neighboring gene Sharpr-MPRA regulatory region 9582 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41138490-41139031 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:41216161-41216333 Neighboring gene RNA, U6 small nuclear 365, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:41266457-41267413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:41324368-41325026 Neighboring gene NANOG hESC enhancer GRCh37_chr11:41414109-41414610 Neighboring gene NANOG hESC enhancer GRCh37_chr11:41448963-41449564 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41519459-41520022 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:41623188-41623333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:41735352-41736094 Neighboring gene long intergenic non-protein coding RNA 2741 Neighboring gene ribosomal protein L9 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Implication of LRRC4C and DPP6 in neurodevelopmental disorders. Maussion G, et al. Am J Med Genet A, 2017 Feb. PMID 27759917, Free PMC Article
  2. Structural basis for cell surface patterning through NetrinG-NGL interactions. Seiradake E, et al. EMBO J, 2011 Sep 23. PMID 21946559, Free PMC Article
  3. Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. Song YS, et al. J Cell Sci, 2013 Nov 1. PMID 23986473
  4. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. Lin JC, et al. Nat Neurosci, 2003 Dec. PMID 14595443
  5. Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Delprat B, et al. Hum Mol Genet, 2005 Feb 1. PMID 15590698

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders.
    Title: Implication of LRRC4C and DPP6 in neurodevelopmental disorders.
  2. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
    Title: Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.
  5. netrin-G1 functions as an important component of the NGL-1 receptor to promote TCA outgrowth and that membrane-bound netrins can participate in receiving axonal signaling pathways.
    Title: The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.
  6. NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons.
    Title: The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
EBI GWAS Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1580

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell-cell adhesion mediator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic membrane adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic membrane adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 4C
Names
netrin-G ligand-1
netrin-G1 ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258419.2 → NP_001245348.1  leucine-rich repeat-containing protein 4C precursor

    See identical proteins and their annotated locations for NP_001245348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB046800, AC090138, BX951676, DQ084201, DQ084202
    Consensus CDS
    CCDS31464.1
    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Related
    ENSP00000437132.1, ENST00000528697.6
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. NM_020929.3 → NP_065980.1  leucine-rich repeat-containing protein 4C precursor

    See identical proteins and their annotated locations for NP_065980.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB046800, AC090138, DA387604, DQ084201, DQ084202
    Consensus CDS
    CCDS31464.1
    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Related
    ENSP00000434761.1, ENST00000530763.5
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RNA

  1. NR_047673.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5'-most exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB046800, AI806109, AK289646, BC041374

  2. NR_047674.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-most exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB046800, AI806109, AY358293, BC041374

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    40114199..41459652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018075.3 → XP_016873564.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. XM_017018073.3 → XP_016873562.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. XM_017018077.3 → XP_016873566.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  4. XM_017018072.3 → XP_016873561.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  5. XM_017018079.3 → XP_016873568.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  6. XM_017018070.3 → XP_016873559.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  7. XM_047427349.1 → XP_047283305.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  8. XM_011520244.4 → XP_011518546.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518546.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  9. XM_011520240.4 → XP_011518542.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518542.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  10. XM_047427352.1 → XP_047283308.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  11. XM_017018071.3 → XP_016873560.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  12. XM_011520243.4 → XP_011518545.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518545.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  13. XM_011520238.4 → XP_011518540.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518540.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  14. XM_011520239.4 → XP_011518541.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518541.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  15. XM_047427350.1 → XP_047283306.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  16. XM_047427351.1 → XP_047283307.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  17. XM_017018074.3 → XP_016873563.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Related
    ENSP00000436976.1, ENST00000527150.5
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  18. XM_011520242.4 → XP_011518544.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518544.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  19. XM_017018076.3 → XP_016873565.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Related
    ENSP00000278198.1, ENST00000278198.2
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  20. XM_011520241.4 → XP_011518543.1  leucine-rich repeat-containing protein 4C isoform X1

    See identical proteins and their annotated locations for XP_011518543.1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  21. XM_017018078.3 → XP_016873567.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
    Conserved Domains (6) summary
    smart00013
    Location:47 → 80
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:301 → 339
    LRRCT; Leucine rich repeat C-terminal domain
    smart00409
    Location:360 → 443
    IG; Immunoglobulin
    sd00033
    Location:78 → 101
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:220 → 279
    LRR_8; Leucine rich repeat
    cd21340
    Location:65 → 235
    PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    40260753..41606210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369515.1 → XP_054225490.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  2. XM_054369509.1 → XP_054225484.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  3. XM_054369523.1 → XP_054225498.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  4. XM_054369507.1 → XP_054225482.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  5. XM_054369528.1 → XP_054225503.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  6. XM_054369508.1 → XP_054225483.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  7. XM_054369510.1 → XP_054225485.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  8. XM_054369524.1 → XP_054225499.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  9. XM_054369506.1 → XP_054225481.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  10. XM_054369527.1 → XP_054225502.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  11. XM_054369522.1 → XP_054225497.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  12. XM_054369516.1 → XP_054225491.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  13. XM_054369520.1 → XP_054225495.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  14. XM_054369521.1 → XP_054225496.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  15. XM_054369512.1 → XP_054225487.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  16. XM_054369511.1 → XP_054225486.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  17. XM_054369513.1 → XP_054225488.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  18. XM_054369525.1 → XP_054225500.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  19. XM_054369514.1 → XP_054225489.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  20. XM_054369519.1 → XP_054225494.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  21. XM_054369518.1 → XP_054225493.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  22. XM_054369529.1 → XP_054225504.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  23. XM_054369517.1 → XP_054225492.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0

  24. XM_054369526.1 → XP_054225501.1  leucine-rich repeat-containing protein 4C isoform X1

    UniProtKB/Swiss-Prot
    A8K0T1, Q7L0N3, Q9HCJ2
    UniProtKB/TrEMBL
    Q4JIW0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HCJ2.1 GenPept UniProtKB/Swiss-Prot:Q9HCJ2

Gene LinkOut

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