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ZDBF2 zinc finger DBF-type containing 2 [ Homo sapiens (human) ]

Gene ID: 57683, updated on 26-Nov-2021

Summary

Official Symbol
ZDBF2provided by HGNC
Official Full Name
zinc finger DBF-type containing 2provided by HGNC
Primary source
HGNC:HGNC:29313
See related
Ensembl:ENSG00000204186 MIM:617059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Slx9
Summary
This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in adrenal (RPKM 4.6), brain (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZDBF2 in Genome Data Viewer
Location:
2q33.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (206273572..206314427)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207139387..207179151)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CMKLR2 antisense RNA Neighboring gene RN7SK pseudogene 260 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 7385 Neighboring gene ACER2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45338, KIAA1571

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA methylation involved in embryo development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in genetic imprinting IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DBF4-type zinc finger-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_045219.1 RefSeqGene

    Range
    5023..44787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1065

mRNA and Protein(s)

  1. NM_001285549.2NP_001272478.1  DBF4-type zinc finger-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001272478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, two additional exons in the 5' region, and initiates translation from an alternate start codon compared to variant 1. The resulting shorter isoform (2) has a novel N-terminus compared to isoform 1.
    Source sequence(s)
    AB775780, AC017081, BQ021839
    UniProtKB/TrEMBL
    N0DVX5
    Related
    ENSP00000478626.1, ENST00000611847.1
  2. NM_001369654.1NP_001356583.1  DBF4-type zinc finger-containing protein 2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC017081
    Related
    ENSP00000497308.1, ENST00000649650.1
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  3. NM_020923.3NP_065974.1  DBF4-type zinc finger-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_065974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB775781, BQ021839
    Consensus CDS
    CCDS46501.1
    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Related
    ENSP00000363545.3, ENST00000374423.9
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    206273572..206314427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004575.2XP_016860064.1  DBF4-type zinc finger-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  2. XM_017004573.2XP_016860062.1  DBF4-type zinc finger-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    N0DVX5
  3. XM_011511532.3XP_011509834.1  DBF4-type zinc finger-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011509834.1

    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  4. XM_017004574.1XP_016860063.1  DBF4-type zinc finger-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    N0DVX5
  5. XM_005246713.3XP_005246770.1  DBF4-type zinc finger-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005246770.1

    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  6. XM_011511533.2XP_011509835.1  DBF4-type zinc finger-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011509835.1

    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  7. XM_011511534.2XP_011509836.1  DBF4-type zinc finger-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011509836.1

    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  8. XM_005246712.5XP_005246769.1  DBF4-type zinc finger-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005246769.1

    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  9. XM_011511535.3XP_011509837.1  DBF4-type zinc finger-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011509837.1

    UniProtKB/Swiss-Prot
    Q9HCK1
    UniProtKB/TrEMBL
    N0DVB2
    Conserved Domains (1) summary
    cl02684
    Location:629
    zf-DBF; DBF zinc finger
  10. XM_017004576.1XP_016860065.1  DBF4-type zinc finger-containing protein 2 isoform X4

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_015495299.1 Reference GRCh38.p13 PATCHES

    Range
    388301..428065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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