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ZFP14 ZFP14 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 57677, updated on 24-Nov-2020

Summary

Official Symbol
ZFP14provided by HGNC
Official Full Name
ZFP14 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:29312
See related
Ensembl:ENSG00000142065
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF531
Expression
Ubiquitous expression in thyroid (RPKM 2.2), endometrium (RPKM 1.7) and 25 other tissues See more
Orthologs

Genomic context

See ZFP14 in Genome Data Viewer
Location:
19q13.12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (36334453..36379201, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36825355..36870126, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134317 Neighboring gene long intergenic non-protein coding RNA 665 Neighboring gene ZFP82 zinc finger protein Neighboring gene acyl-CoA thioesterase 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1559

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blastocyst hatching IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 14 homolog
Names
zinc finger protein 531

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297619.2NP_001284548.1  zinc finger protein 14 homolog isoform 1

    See identical proteins and their annotated locations for NP_001284548.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC092296, AL699477, BC144691, H17024
    Conserved Domains (5) summary
    smart00349
    Location:668
    KRAB; krueppel associated box
    COG5048
    Location:199534
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:455475
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:272296
    zf-H2C2_2; Zinc-finger double domain
  2. NM_020917.3NP_065968.1  zinc finger protein 14 homolog isoform 2

    See identical proteins and their annotated locations for NP_065968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AC092296, AL699477, BC152446, H17024
    Consensus CDS
    CCDS33002.1
    UniProtKB/Swiss-Prot
    Q9HCL3
    Related
    ENSP00000270001.6, ENST00000270001.12
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:198533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:271295
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    36334453..36379201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027038.1XP_016882527.1  zinc finger protein 14 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9HCL3
    Conserved Domains (5) summary
    smart00349
    Location:667
    KRAB; krueppel associated box
    COG5048
    Location:198533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:454474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:271295
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024451625.1XP_024307393.1  zinc finger protein 14 homolog isoform X2

    Conserved Domains (2) summary
    COG5048
    Location:93428
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:349369
    ZF_C2H2; C2H2 Zn finger [structural motif]
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