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USP29 ubiquitin specific peptidase 29 [ Homo sapiens (human) ]

Gene ID: 57663, updated on 25-Nov-2021

Summary

Official Symbol
USP29provided by HGNC
Official Full Name
ubiquitin specific peptidase 29provided by HGNC
Primary source
HGNC:HGNC:18563
See related
Ensembl:ENSG00000131864 MIM:609546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOM-TES-84/86
Expression
Restricted expression toward testis (RPKM 2.8) See more
Orthologs
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Genomic context

See USP29 in Genome Data Viewer
Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57119087..57131983)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57631509..57643294)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372475 Neighboring gene Sharpr-MPRA regulatory region 3098 Neighboring gene zinc finger protein 300 pseudogene Neighboring gene zinc finger imprinted 3 Neighboring gene double homeobox A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163266, MGC163270

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 29
Names
deubiquitinating enzyme 29
ubiquitin thioesterase 29
ubiquitin thiolesterase 29
ubiquitin-specific processing protease
ubiquitin-specific-processing protease 29
NP_001376572.1
NP_065954.1
XP_024307392.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389643.1NP_001376572.1  ubiquitin carboxyl-terminal hydrolase 29

    Status: VALIDATED

    Source sequence(s)
    AC025588
    Related
    ENSP00000470747.1, ENST00000598197.1
    Conserved Domains (3) summary
    cd02257
    Location:823883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286552
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_020903.3NP_065954.1  ubiquitin carboxyl-terminal hydrolase 29

    See identical proteins and their annotated locations for NP_065954.1

    Status: VALIDATED

    Source sequence(s)
    AC025588
    Consensus CDS
    CCDS33124.1
    UniProtKB/Swiss-Prot
    Q9HBJ7
    Related
    ENSP00000254181.3, ENST00000254181.8
    Conserved Domains (3) summary
    cd02257
    Location:823883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286552
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57119087..57131983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451624.1XP_024307392.1  ubiquitin carboxyl-terminal hydrolase 29 isoform X1

    Conserved Domains (3) summary
    cd02257
    Location:823883
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd13312
    Location:4106
    PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37
    pfam00443
    Location:286552
    UCH; Ubiquitin carboxyl-terminal hydrolase
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