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DHX37 DEAH-box helicase 37 [ Homo sapiens (human) ]

Gene ID: 57647, updated on 8-Jul-2021

Summary

Official Symbol
DHX37provided by HGNC
Official Full Name
DEAH-box helicase 37provided by HGNC
Primary source
HGNC:HGNC:17210
See related
Ensembl:ENSG00000150990 MIM:617362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Dhr1; DDX37; SRXY11; NEDBAVC
Summary
This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 4.6), lymph node (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See DHX37 in Genome Data Viewer
Location:
12q24.31
Exon count:
28
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (124946824..124989131, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125431372..125473677, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene tRNA-Asp (anticodon GTC) 2-10 Neighboring gene tRNA-Ala (anticodon TGC) 4-1 Neighboring gene BRI3 binding protein Neighboring gene TNF and HNRNPL related immunoregulatory long non-coding RNA Neighboring gene translocase of outer mitochondrial membrane 6 homolog (yeast) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2695, MGC4322, FLJ41974, KIAA1517, MGC46245

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables U3 snoRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DHX37
Names
DEAD/DEAH box helicase DDX37
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 37
DEAH (Asp-Glu-Ala-His) box polypeptide 37
DEAH box protein 37
NP_116045.2
XP_005253647.1
XP_011536900.1
XP_011536902.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032656.4NP_116045.2  probable ATP-dependent RNA helicase DHX37

    See identical proteins and their annotated locations for NP_116045.2

    Status: REVIEWED

    Source sequence(s)
    AC093719, BC037964, BU633279
    Consensus CDS
    CCDS9261.1
    UniProtKB/Swiss-Prot
    Q8IY37
    Related
    ENSP00000311135.2, ENST00000308736.7
    Conserved Domains (6) summary
    smart00490
    Location:585674
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:768859
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:2401016
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:271411
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:8941011
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    cl21455
    Location:368511
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    124946824..124989131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253590.3XP_005253647.1  probable ATP-dependent RNA helicase DHX37 isoform X1

    Related
    ENSP00000439009.2, ENST00000544745.2
    Conserved Domains (6) summary
    smart00490
    Location:585674
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:768859
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:2401016
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:271411
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:8941011
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    cl21455
    Location:368511
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011538600.2XP_011536902.1  probable ATP-dependent RNA helicase DHX37 isoform X3

    See identical proteins and their annotated locations for XP_011536902.1

    Conserved Domains (5) summary
    smart00490
    Location:585674
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:768857
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:240837
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:271411
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cl21455
    Location:368511
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011538598.2XP_011536900.1  probable ATP-dependent RNA helicase DHX37 isoform X2

    Conserved Domains (5) summary
    smart00490
    Location:585674
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:768859
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:240895
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:271411
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cl21455
    Location:368511
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_001748820.1 RNA Sequence

  2. XR_001748819.1 RNA Sequence

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