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NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 [ Homo sapiens (human) ]

Gene ID: 57624, updated on 26-Oct-2022

Summary

Official Symbol
NYAP2provided by HGNC
Official Full Name
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2provided by HGNC
Primary source
HGNC:HGNC:29291
See related
Ensembl:ENSG00000144460 MIM:615478; AllianceGenome:HGNC:29291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1486
Summary
Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase signaling. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NYAP2 in Genome Data Viewer
Location:
2q36.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (225397939..225703654)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (225881563..226185592)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (226264426..226568370)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 10 Neighboring gene uncharacterized LOC124906121 Neighboring gene microRNA 4439 Neighboring gene uncharacterized LOC105373914 Neighboring gene uncharacterized LOC107985992 Neighboring gene Sharpr-MPRA regulatory region 10559

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study of early menopause and the combined impact of identified variants.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1486, AC067961.1

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371273.1NP_001358202.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016717, AC019231, AC067961
    Consensus CDS
    CCDS92950.1
    Related
    ENSP00000272907.7, ENST00000272907.8
    Conserved Domains (2) summary
    pfam15439
    Location:56431
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:472719
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
  2. NM_020864.2NP_065915.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform 2

    See identical proteins and their annotated locations for NP_065915.1

    Status: VALIDATED

    Source sequence(s)
    AB040919, AC019231, AC067961, DA230522
    Consensus CDS
    CCDS46529.1
    UniProtKB/Swiss-Prot
    Q96NL2, Q9P242
    Related
    ENSP00000490942.1, ENST00000636099.1
    Conserved Domains (2) summary
    pfam15439
    Location:56431
    NYAP_N; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
    pfam15452
    Location:472647
    NYAP_C; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    225397939..225703654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445201.1XP_047301157.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X1

  2. XM_047445200.1XP_047301156.1  neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    225881563..226185592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)