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SLAIN2 SLAIN motif family member 2 [ Homo sapiens (human) ]

Gene ID: 57606, updated on 6-Nov-2022

Summary

Official Symbol
SLAIN2provided by HGNC
Official Full Name
SLAIN motif family member 2provided by HGNC
Primary source
HGNC:HGNC:29282
See related
Ensembl:ENSG00000109171 MIM:610492; AllianceGenome:HGNC:29282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1458
Summary
Involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Located in centrosome and cytosol. Colocalizes with microtubule plus-end. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 22.9), esophagus (RPKM 14.0) and 25 other tissues See more
Orthologs
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Genomic context

See SLAIN2 in Genome Data Viewer
Location:
4p11
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (48341529..48426201)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (48308531..48393241)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (48343546..48428218)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374445 Neighboring gene Sharpr-MPRA regulatory region 3457 Neighboring gene U6 snRNA-associated Sm-like protein LSm2 Neighboring gene CRISPRi-validated cis-regulatory element chr4.1483 Neighboring gene solute carrier family 10 member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21611

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule nucleation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SLAIN motif-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020846.2NP_065897.1  SLAIN motif-containing protein 2

    See identical proteins and their annotated locations for NP_065897.1

    Status: VALIDATED

    Source sequence(s)
    AB040891, AC096952, AC098873, BC040993, CB157681, Z25182
    Consensus CDS
    CCDS47051.1
    UniProtKB/Swiss-Prot
    Q8N5R3, Q9P270
    UniProtKB/TrEMBL
    A0A024R9T6, A0A158RFV0
    Related
    ENSP00000264313.5, ENST00000264313.11
    Conserved Domains (1) summary
    pfam15301
    Location:130581
    SLAIN; SLAIN motif-containing family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    48341529..48426201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248121.4XP_005248178.1  SLAIN motif-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15301
    Location:130607
    SLAIN; SLAIN motif-containing family
  2. XM_047416023.1XP_047271979.1  SLAIN motif-containing protein 2 isoform X2

    Related
    ENSP00000425923.1, ENST00000512093.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    48308531..48393241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)