Format

Send to:

Choose Destination

USP36 ubiquitin specific peptidase 36 [ Homo sapiens (human) ]

Gene ID: 57602, updated on 12-Oct-2019

Summary

Official Symbol
USP36provided by HGNC
Official Full Name
ubiquitin specific peptidase 36provided by HGNC
Primary source
HGNC:HGNC:20062
See related
Ensembl:ENSG00000055483 MIM:612543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUB1
Summary
This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 11.2), adrenal (RPKM 8.5) and 25 other tissues See more
Orthologs

Genomic context

See USP36 in Genome Data Viewer
Location:
17q25.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (78787381..78840840, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76783463..76836980, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268196 Neighboring gene cytohesin 1 Neighboring gene RNA, U6 small nuclear 638, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3779 Neighboring gene ribosomal protein L9 pseudogene 29 Neighboring gene TIMP metallopeptidase inhibitor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
histone deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleolus organization IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus organization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to mitochondrion HMP PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of autophagy of mitochondrion HMP PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 36
Names
deubiquitinating enzyme 36
ubiquitin specific protease 36
ubiquitin thioesterase 36
ubiquitin-specific-processing protease 36
NP_001308220.1
XP_005257599.1
XP_005257600.1
XP_011523367.1
XP_011523368.1
XP_011523369.1
XP_011523370.1
XP_011523371.1
XP_011523372.1
XP_011523373.1
XP_016880389.1
XP_016880390.1
XP_024306613.1
XP_024306614.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321291.1NP_001308220.1  ubiquitin carboxyl-terminal hydrolase 36

    Status: REVIEWED

    Source sequence(s)
    AC022966, AK023077, AL359624, BC071582
    Consensus CDS
    CCDS32755.1
    UniProtKB/Swiss-Prot
    Q9P275
    UniProtKB/TrEMBL
    A0A024R8V6
    Related
    ENSP00000441214.1, ENST00000542802.7
    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    78787381..78840840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024900.2XP_016880389.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    UniProtKB/TrEMBL
    A0A024R8V6
    Related
    ENSP00000468549.2, ENST00000588086.5
    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  2. XM_011525067.3XP_011523369.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_011523369.1

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  3. XM_011525071.3XP_011523373.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X7

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:122420
    UCH; Ubiquitin carboxyl-terminal hydrolase
  4. XM_011525065.2XP_011523367.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_011523367.1

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  5. XM_005257542.3XP_005257599.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    See identical proteins and their annotated locations for XP_005257599.1

    UniProtKB/TrEMBL
    A0A024R8V6
    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  6. XM_005257543.3XP_005257600.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X2

    See identical proteins and their annotated locations for XP_005257600.1

    UniProtKB/TrEMBL
    A0A024R8V6
    Related
    ENSP00000467280.1, ENST00000589225.5
    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  7. XM_011525069.3XP_011523371.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X5

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:122420
    UCH; Ubiquitin carboxyl-terminal hydrolase
  8. XM_011525066.3XP_011523368.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    See identical proteins and their annotated locations for XP_011523368.1

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  9. XM_011525068.1XP_011523370.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X4

    Conserved Domains (2) summary
    cd02661
    Location:1256
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1255
    UCH; Ubiquitin carboxyl-terminal hydrolase
  10. XM_011525070.2XP_011523372.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X6

    Conserved Domains (2) summary
    cl02553
    Location:21211
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:23210
    UCH; Ubiquitin carboxyl-terminal hydrolase
  11. XM_024450845.1XP_024306613.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  12. XM_024450846.1XP_024306614.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X1

    Conserved Domains (2) summary
    cd02661
    Location:121421
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl26464
    Location:506840
    Atrophin-1; Atrophin-1 family
  13. XM_017024901.1XP_016880390.1  ubiquitin carboxyl-terminal hydrolase 36 isoform X3

RNA

  1. XR_001752573.2 RNA Sequence

  2. XR_934510.3 RNA Sequence

  3. XR_001752574.2 RNA Sequence

  4. XR_001752572.2 RNA Sequence

  5. XR_002958048.1 RNA Sequence

  6. XR_001752575.2 RNA Sequence

  7. XR_002958049.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_025090.3: Suppressed sequence

    Description
    NM_025090.3: This RefSeq was removed because currently there is not sufficient data to support this transcript.
Support Center