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SYT13 synaptotagmin 13 [ Homo sapiens (human) ]

Gene ID: 57586, updated on 5-Nov-2017
Official Symbol
SYT13provided by HGNC
Official Full Name
synaptotagmin 13provided by HGNC
Primary source
HGNC:HGNC:14962
See related
Ensembl:ENSG00000019505 MIM:607716; Vega:OTTHUMG00000166504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the large synaptotagmin protein family. Family members have an extracellular N-terminal transmembrane domain and a cytoplasmic C terminus with two tandem C2 domains (C2A and C2B). Synaptotogmin family members can form homo- and heteromeric complexes with each other. They also have different biochemical properties and developmental profiles, and patterns of tissue distribution. Synaptotagmins function as membrane traffickers in multicellular organisms. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Orthologs
Location:
11p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (45240302..45286333, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (45261853..45307884, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376652 Neighboring gene PR/SET domain 11 Neighboring gene uncharacterized LOC101060179 Neighboring gene uncharacterized LOC101928812 Neighboring gene uncharacterized LOC399886

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of synaptotagmin XIII (SYT13) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IDA
Inferred from Direct Assay
more info
 
Preferred Names
synaptotagmin-13
Names
synaptotagmin XIII
sytXIII

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001247987.1NP_001234916.1  synaptotagmin-13 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains additional exons in the 5' end, which result in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC103681, AC103736, AK308841, W45345
    Conserved Domains (2) summary
    cd08407
    Location:144281
    C2B_Synaptotagmin-13; C2 domain second repeat present in Synaptotagmin 13
    cd08677
    Location:16133
    C2A_Synaptotagmin-13; C2 domain
  2. NM_020826.2NP_065877.1  synaptotagmin-13 isoform 1

    See identical proteins and their annotated locations for NP_065877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AB037848, AC103681, AL512743, BP251101
    Consensus CDS
    CCDS31470.1
    UniProtKB/Swiss-Prot
    Q7L8C5
    Related
    ENSP00000020926.3, OTTHUMP00000233113, ENST00000020926.7, OTTHUMT00000390110
    Conserved Domains (2) summary
    cd08407
    Location:288425
    C2B_Synaptotagmin-13; C2 domain second repeat present in Synaptotagmin 13
    cd08677
    Location:160277
    C2A_Synaptotagmin-13; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    45240302..45286333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    45260943..45306976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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