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TMEM181 transmembrane protein 181 [ Homo sapiens (human) ]

Gene ID: 57583, updated on 26-Oct-2022

Summary

Official Symbol
TMEM181provided by HGNC
Official Full Name
transmembrane protein 181provided by HGNC
Primary source
HGNC:HGNC:20958
See related
Ensembl:ENSG00000146433 MIM:613209; AllianceGenome:HGNC:20958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR178; KIAA1423
Summary
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
Expression
Ubiquitous expression in stomach (RPKM 9.9), testis (RPKM 9.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM181 in Genome Data Viewer
Location:
6q25.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (158536640..158635429)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (159781619..159880620)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (158957672..159056461)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TUB like protein 4 Neighboring gene RNA, 7SL, cytoplasmic 173, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4140 Neighboring gene Sharpr-MPRA regulatory region 10808 Neighboring gene calcyclin binding protein pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 807 Neighboring gene TatD DNase domain containing 2 pseudogene 2 Neighboring gene microRNA 7161 Neighboring gene dynein light chain Tctex-type 1 Neighboring gene synaptotagmin like 3 Neighboring gene AMZ2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transmembrane protein 181 (TMEM181) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables toxic substance binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables toxic substance binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 181
Names
G protein-coupled receptor 178

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376817.1NP_001363746.1  transmembrane protein 181 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:177472
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  2. NM_001376850.1NP_001363779.1  transmembrane protein 181 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:136431
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  3. NM_001376852.1NP_001363781.1  transmembrane protein 181 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Consensus CDS
    CCDS94026.1
    UniProtKB/TrEMBL
    A0A804HII6
    Related
    ENSP00000507085.1, ENST00000684151.1
    Conserved Domains (1) summary
    pfam06664
    Location:128423
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  4. NM_001376854.1NP_001363783.1  transmembrane protein 181 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:128396
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  5. NM_001376855.1NP_001363784.1  transmembrane protein 181 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:96391
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  6. NM_001376856.1NP_001363785.1  transmembrane protein 181 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Conserved Domains (1) summary
    pfam06664
    Location:47342
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  7. NM_020823.2NP_065874.2  transmembrane protein 181 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591025
    Consensus CDS
    CCDS43520.2
    Related
    ENSP00000356057.4, ENST00000367090.4
    Conserved Domains (1) summary
    pfam06664
    Location:170464
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RNA

  1. NR_164859.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591025

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    158536640..158635429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536000.2XP_011534302.2  transmembrane protein 181 isoform X1

  2. XM_011536003.3XP_011534305.2  transmembrane protein 181 isoform X5

  3. XM_047419182.1XP_047275138.1  transmembrane protein 181 isoform X6

  4. XM_047419183.1XP_047275139.1  transmembrane protein 181 isoform X7

  5. XM_047419185.1XP_047275141.1  transmembrane protein 181 isoform X9

  6. XM_047419187.1XP_047275143.1  transmembrane protein 181 isoform X10

  7. XM_011536001.3XP_011534303.1  transmembrane protein 181 isoform X3

    Conserved Domains (1) summary
    pfam06664
    Location:154449
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  8. XM_011536002.3XP_011534304.1  transmembrane protein 181 isoform X4

    Conserved Domains (1) summary
    pfam06664
    Location:146441
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
  9. XM_047419184.1XP_047275140.1  transmembrane protein 181 isoform X8

  10. XM_047419181.1XP_047275137.1  transmembrane protein 181 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    159781619..159880620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)