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KIF17 kinesin family member 17 [ Homo sapiens (human) ]

Gene ID: 57576, updated on 3-Jun-2018
Official Symbol
KIF17provided by HGNC
Official Full Name
kinesin family member 17provided by HGNC
Primary source
HGNC:HGNC:19167
See related
Ensembl:ENSG00000117245 MIM:605037; Vega:OTTHUMG00000002863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIF3X; KLP-2; OSM-3; KIF17B
Expression
Biased expression in testis (RPKM 11.7), spleen (RPKM 7.5) and 6 other tissues See more
Orthologs
See KIF17 in Genome Data Viewer
Location:
1p36.12
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (20664014..20718017, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20990475..21044317, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 6084 Neighboring gene PTEN induced putative kinase 1 Neighboring gene PINK1 antisense RNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Neighboring gene SH2 domain containing 5 Neighboring gene uncharacterized LOC112268222 Neighboring gene heterochromatin protein 1 binding protein 3

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of kinesin family member 17 (KIF17) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of kinesin family member 17 is significantly upregulated in clade B treated SK-N-MC neuroblastoma cells but downregulated in clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Intraflagellar transport, organism-specific biosystem (from REACTOME)
    Intraflagellar transport, organism-specific biosystemIntraflagellar transport (IFT) is a motor-based process that controls the anterograde and retrograde transport of large protein complexes, ciliary cargo and structural components along the ciliary ax...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1405

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anterograde dendritic transport of neurotransmitter receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anterograde dendritic transport of neurotransmitter receptor complex IEA
Inferred from Electronic Annotation
more info
 
cell projection organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axoneme IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
cilium TAS
Traceable Author Statement
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intraciliary transport particle B IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
periciliary membrane compartment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor connecting cilium IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kinesin-like protein KIF17
Names
KIF17 variant protein
KIF3-related motor protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122819.2NP_001116291.1  kinesin-like protein KIF17 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AL663074, AY484427, BC040639, BC065927, BX387401
    Consensus CDS
    CCDS44079.1
    UniProtKB/Swiss-Prot
    Q9P2E2
    Related
    ENSP00000383311.3, OTTHUMP00000179077, ENST00000400463.7, OTTHUMT00000008012
    Conserved Domains (2) summary
    cl22853
    Location:4335
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:11335
    Kinesin; Kinesin motor domain
  2. NM_001287212.1NP_001274141.1  kinesin-like protein KIF17 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AB037826, AL663074, AY484427, BC040639, BC065927, BX387401
    Consensus CDS
    CCDS72722.1
    UniProtKB/Swiss-Prot
    Q9P2E2
    UniProtKB/TrEMBL
    A0A0A0MRS8
    Related
    ENSP00000364184.1, OTTHUMP00000002887, ENST00000375044.5, OTTHUMT00000008009
    Conserved Domains (2) summary
    cl22853
    Location:1235
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:1235
    Kinesin; Kinesin motor domain
  3. NM_020816.3NP_065867.2  kinesin-like protein KIF17 isoform a

    See identical proteins and their annotated locations for NP_065867.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL663074, AY484427, BC040639, BC065927, BX387401
    Consensus CDS
    CCDS213.1
    UniProtKB/Swiss-Prot
    Q9P2E2
    Related
    ENSP00000247986.2, OTTHUMP00000179076, ENST00000247986.2, OTTHUMT00000276995
    Conserved Domains (2) summary
    cl22853
    Location:4335
    Motor_domain; Myosin and Kinesin motor domain
    pfam00225
    Location:11335
    Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    20664014..20718017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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