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PCDH10 protocadherin 10 [ Homo sapiens (human) ]

Gene ID: 57575, updated on 23-Nov-2021

Summary

Official Symbol
PCDH10provided by HGNC
Official Full Name
protocadherin 10provided by HGNC
Primary source
HGNC:HGNC:13404
See related
Ensembl:ENSG00000138650 MIM:608286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCDH19; OL-PCDH
Summary
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Expression
Biased expression in brain (RPKM 21.3), placenta (RPKM 10.2) and 4 other tissues See more
Orthologs
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Genomic context

See PCDH10 in Genome Data Viewer
Location:
4q28.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (133149294..133208606)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (134070449..134115855)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377432 Neighboring gene PCDH10 divergent transcript Neighboring gene R3H domain containing 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 13606 Neighboring gene poly(A) binding protein cytoplasmic 4 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1400, MGC133344, DKFZp761O2023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020815.3NP_065866.1  protocadherin-10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_065866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is intronless, and its 3' terminal end extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter, and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC105383, AI479918, AW007480, AY013874, CX760781, DA318338
    Consensus CDS
    CCDS75192.1
    UniProtKB/Swiss-Prot
    Q9P2E7
    Related
    ENSP00000480512.1, ENST00000618019.1
    Conserved Domains (3) summary
    cd11304
    Location:254354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal
  2. NM_032961.3NP_116586.1  protocadherin-10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_116586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB037821, AC105383, AL157470, BC039411, CB052787, DA318338
    Consensus CDS
    CCDS34063.1
    UniProtKB/Swiss-Prot
    Q9P2E7
    UniProtKB/TrEMBL
    Q9NSR3, X5D999
    Related
    ENSP00000264360.4, ENST00000264360.7
    Conserved Domains (3) summary
    cd11304
    Location:254354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    133149294..133208606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532150.2XP_011530452.1  protocadherin-10 isoform X1

    Conserved Domains (3) summary
    cd11304
    Location:254354
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam08266
    Location:19101
    Cadherin_2; Cadherin-like
    pfam16492
    Location:713838
    Cadherin_C_2; Cadherin cytoplasmic C-terminal
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