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PTMA prothymosin alpha [ Homo sapiens (human) ]

Gene ID: 5757, updated on 4-Jul-2021

Summary

Official Symbol
PTMAprovided by HGNC
Official Full Name
prothymosin alphaprovided by HGNC
Primary source
HGNC:HGNC:9623
See related
Ensembl:ENSG00000187514 MIM:188390
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMSA
Expression
Ubiquitous expression in bone marrow (RPKM 272.9), lymph node (RPKM 218.9) and 25 other tissues See more
Orthologs
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Genomic context

See PTMA in Genome Data Viewer
Location:
2q37.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (231708525..231713551)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232573235..232578261)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 499, pseudogene Neighboring gene RN7SL499P-PTMA intergenic region enhancers Neighboring gene Sharpr-MPRA regulatory region 12341 Neighboring gene microRNA 1244-1 Neighboring gene phosphodiesterase 6D Neighboring gene Sharpr-MPRA regulatory region 13150

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with disordered eating.
GeneReviews: Not available
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of prothymosin alpha by siRNA enhances HIV-1 replication in macrophages through the downregulation of type I interferon PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev prothymosin alpha has been identified through the use of a Rev affinity column as specifically binding to the activation domain of Rev (amino acids 75-83) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104802

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
prothymosin alpha
Names
gene sequence 28
prothymosin alpha protein
prothymosin-I+/-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099285.2NP_001092755.1  prothymosin alpha isoform 1

    See identical proteins and their annotated locations for NP_001092755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC073476, BC071879, BM839980, M14630
    Consensus CDS
    CCDS42833.1
    UniProtKB/Swiss-Prot
    P06454
    Related
    ENSP00000344547.7, ENST00000341369.11
    Conserved Domains (1) summary
    pfam03247
    Location:2110
    Prothymosin; Prothymosin/parathymosin family
  2. NM_002823.5NP_002814.3  prothymosin alpha isoform 2

    See identical proteins and their annotated locations for NP_002814.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC073476, BC071879, BM839980
    Consensus CDS
    CCDS46541.1
    UniProtKB/Swiss-Prot
    P06454
    UniProtKB/TrEMBL
    Q53S24
    Related
    ENSP00000386819.3, ENST00000409115.8
    Conserved Domains (1) summary
    pfam03247
    Location:2109
    Prothymosin; Prothymosin/parathymosin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    231708525..231713551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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