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STAMBPL1 STAM binding protein like 1 [ Homo sapiens (human) ]

Gene ID: 57559, updated on 8-Nov-2022

Summary

Official Symbol
STAMBPL1provided by HGNC
Official Full Name
STAM binding protein like 1provided by HGNC
Primary source
HGNC:HGNC:24105
See related
Ensembl:ENSG00000138134 MIM:612352; AllianceGenome:HGNC:24105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2
Summary
Predicted to enable Lys63-specific deubiquitinase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein K63-linked deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal (RPKM 7.5), testis (RPKM 6.2) and 22 other tissues See more
Orthologs
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Genomic context

See STAMBPL1 in Genome Data Viewer
Location:
10q23.31
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88880245..88923487)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89764187..89807429)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90640002..90683244)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene uncharacterized LOC124902551 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene ACTA2 antisense RNA 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene Fas cell surface death receptor Neighboring gene FAS antisense RNA 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31524, KIAA1373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables K63-linked deubiquitinase activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal-dependent deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
AMSH-like protease
Names
associated molecule with the SH3 domain of STAM (AMSH) - Family Protein
associated molecule with the SH3 domain of STAM (AMSH) like protein
NP_065850.1
XP_006717993.1
XP_011538285.1
XP_011538287.1
XP_016871945.1
XP_016871946.1
XP_016871947.1
XP_047281507.1
XP_047281508.1
XP_047281509.1
XP_047281510.1
XP_047281511.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020799.4NP_065850.1  AMSH-like protease

    See identical proteins and their annotated locations for NP_065850.1

    Status: VALIDATED

    Source sequence(s)
    AK056086, AW006657, CD244526
    Consensus CDS
    CCDS7391.1
    UniProtKB/Swiss-Prot
    Q96FJ0, Q9P2H4
    Related
    ENSP00000360994.3, ENST00000371926.8
    Conserved Domains (3) summary
    cd08066
    Location:266436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120198
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    88880245..88923487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425551.1XP_047281507.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H4
  2. XM_011539985.3XP_011538287.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_011538287.1

    UniProtKB/Swiss-Prot
    Q96FJ0, Q9P2H4
    Conserved Domains (3) summary
    cd08066
    Location:266436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120198
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. XM_006717930.4XP_006717993.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_006717993.1

    UniProtKB/Swiss-Prot
    Q96FJ0, Q9P2H4
    Conserved Domains (3) summary
    cd08066
    Location:266436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120198
    GBP_C; Guanylate-binding protein, C-terminal domain
  4. XM_047425553.1XP_047281509.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H4
  5. XM_011539983.2XP_011538285.1  AMSH-like protease isoform X1

    See identical proteins and their annotated locations for XP_011538285.1

    UniProtKB/Swiss-Prot
    Q96FJ0, Q9P2H4
    Conserved Domains (3) summary
    cd08066
    Location:266436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120198
    GBP_C; Guanylate-binding protein, C-terminal domain
  6. XM_047425555.1XP_047281511.1  AMSH-like protease isoform X2

  7. XM_047425552.1XP_047281508.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H4
  8. XM_017016456.2XP_016871945.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    Q96FJ0, Q9P2H4
    Conserved Domains (3) summary
    cd08066
    Location:266436
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:28129
    USP8_dimer; USP8 dimerization domain
    cl20817
    Location:120198
    GBP_C; Guanylate-binding protein, C-terminal domain
  9. XM_017016457.3XP_016871946.1  AMSH-like protease isoform X2

  10. XM_047425554.1XP_047281510.1  AMSH-like protease isoform X1

    UniProtKB/Swiss-Prot
    Q9P2H4
  11. XM_017016458.2XP_016871947.1  AMSH-like protease isoform X3

    Conserved Domains (2) summary
    cd08066
    Location:160330
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    COG0544
    Location:1391
    Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    89764187..89807429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)