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USP35 ubiquitin specific peptidase 35 [ Homo sapiens (human) ]

Gene ID: 57558, updated on 28-Nov-2021

Summary

Official Symbol
USP35provided by HGNC
Official Full Name
ubiquitin specific peptidase 35provided by HGNC
Primary source
HGNC:HGNC:20061
See related
Ensembl:ENSG00000118369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in adrenal (RPKM 3.3), brain (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See USP35 in Genome Data Viewer
Location:
11q14.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (78188815..78226184)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77899965..77926278)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ALG8 alpha-1,3-glucosyltransferase Neighboring gene RNA, U6 small nuclear 126, pseudogene Neighboring gene KCTD21 antisense RNA 1 Neighboring gene potassium channel tetramerization domain containing 21 Neighboring gene GRB2 associated binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 2371 Neighboring gene uncharacterized LOC105369402

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 35
Names
deubiquitinating enzyme 35
ubiquitin specific protease 35
ubiquitin thioesterase 35
ubiquitin thiolesterase 35
ubiquitin-specific-processing protease 35
NP_065849.1
XP_011543489.1
XP_011543490.1
XP_016873542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020798.4NP_065849.1  ubiquitin carboxyl-terminal hydrolase 35

    See identical proteins and their annotated locations for NP_065849.1

    Status: REVIEWED

    Source sequence(s)
    AB037793, AI263341, AJ586137, AK056231, AP002985, CN287538, DB095282
    Consensus CDS
    CCDS41693.1
    UniProtKB/Swiss-Prot
    Q9P2H5
    Related
    ENSP00000431876.1, ENST00000529308.6
    Conserved Domains (2) summary
    cl02553
    Location:442924
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:441923
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    78188815..78226184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018053.1XP_016873542.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X1

    Conserved Domains (2) summary
    cl02553
    Location:198680
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:197679
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. XM_011545187.2XP_011543489.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    See identical proteins and their annotated locations for XP_011543489.1

    UniProtKB/Swiss-Prot
    Q9P2H5
    Conserved Domains (2) summary
    cl02553
    Location:173655
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:172654
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. XM_011545188.2XP_011543490.1  ubiquitin carboxyl-terminal hydrolase 35 isoform X2

    See identical proteins and their annotated locations for XP_011543490.1

    UniProtKB/Swiss-Prot
    Q9P2H5
    Related
    ENSP00000434942.1, ENST00000526425.1
    Conserved Domains (2) summary
    cl02553
    Location:173655
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:172654
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. XR_001747928.1 RNA Sequence

  2. XR_001747931.1 RNA Sequence

  3. XR_001747930.1 RNA Sequence

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