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NLGN2 neuroligin 2 [ Homo sapiens (human) ]

Gene ID: 57555, updated on 12-Aug-2018

Summary

Official Symbol
NLGN2provided by HGNC
Official Full Name
neuroligin 2provided by HGNC
Primary source
HGNC:HGNC:14290
See related
Ensembl:ENSG00000169992 MIM:606479; Vega:OTTHUMG00000108138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 29.8), endometrium (RPKM 15.7) and 20 other tissues See more
Orthologs

Genomic context

See NLGN2 in Genome Data Viewer
Location:
17p13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (7405492..7419864)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7311502..7323183)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tyrosine kinase non receptor 1 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 256 Neighboring gene spermatid maturation 1 Neighboring gene SPEM family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NLGN2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurexin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neurexin family protein binding NAS
Non-traceable Author Statement
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell-cell junction maintenance NAS
Non-traceable Author Statement
more info
PubMed 
gephyrin clustering involved in postsynaptic density assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
inhibitory synapse assembly IEA
Inferred from Electronic Annotation
more info
 
locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
neuron cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to synapse IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density protein 95 clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
presynapse assembly TAS
Traceable Author Statement
more info
PubMed 
presynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of respiratory gaseous exchange by neurological system process ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal button organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
dopaminergic synapse IEA
Inferred from Electronic Annotation
more info
 
glycinergic synapse IEA
Inferred from Electronic Annotation
more info
 
inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
spanning component of membrane TAS
Traceable Author Statement
more info
PubMed 
symmetric, GABA-ergic, inhibitory synapse TAS
Traceable Author Statement
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020795.3NP_065846.1  neuroligin-2 precursor

    See identical proteins and their annotated locations for NP_065846.1

    Status: REVIEWED

    Source sequence(s)
    AA447769, AC113189, AF376802, AI613237, BI868885, BM800364, DR763679, EL949788
    Consensus CDS
    CCDS11103.1
    UniProtKB/Swiss-Prot
    Q8NFZ4
    Related
    ENSP00000305288.2, OTTHUMP00000135277, ENST00000302926.6, OTTHUMT00000226941
    Conserved Domains (2) summary
    COG0657
    Location:170268
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:41601
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    7405492..7419864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024897.1XP_016880386.1  neuroligin-2 isoform X2

    Conserved Domains (2) summary
    COG0657
    Location:189
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:1422
    COesterase; Carboxylesterase family
  2. XM_005256744.4XP_005256801.1  neuroligin-2 isoform X1

    Conserved Domains (2) summary
    COG0657
    Location:87251
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:41584
    COesterase; Carboxylesterase family

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p12 PATCHES

    Range
    28640..40321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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