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NLGN2 neuroligin 2 [ Homo sapiens (human) ]

Gene ID: 57555, updated on 5-Aug-2022

Summary

Official Symbol
NLGN2provided by HGNC
Official Full Name
neuroligin 2provided by HGNC
Primary source
HGNC:HGNC:14290
See related
Ensembl:ENSG00000169992 MIM:606479; AllianceGenome:HGNC:14290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 29.8), endometrium (RPKM 15.7) and 20 other tissues See more
Orthologs
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Genomic context

See NLGN2 in Genome Data Viewer
Location:
17p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7404653..7419860)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7311889..7323908)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7311164..7323179)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tyrosine kinase non receptor 1 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene phospholipid scramblase 3 Neighboring gene transmembrane protein 256 Neighboring gene spermatid maturation 1 Neighboring gene SPEM family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NLGN2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurexin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables neurexin family protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-cell junction maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gephyrin clustering involved in postsynaptic density assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inhibitory synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in insulin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in jump response IEA
Inferred from Electronic Annotation
more info
 
involved_in locomotory exploration behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neurotransmitter-gated ion channel clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inhibitory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein localization to synapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of t-SNARE clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in postsynaptic density protein 95 clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in postsynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in postsynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in presynapse assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in presynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in presynaptic membrane assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of respiratory gaseous exchange by nervous system process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in terminal button organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in thigmotaxis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
located_in dopaminergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
located_in glycinergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in inhibitory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of postsynaptic specialization membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in ribbon synapse IEA
Inferred from Electronic Annotation
more info
 
located_in spanning component of membrane TAS
Traceable Author Statement
more info
PubMed 
located_in symmetric, GABA-ergic, inhibitory synapse TAS
Traceable Author Statement
more info
PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020795.4NP_065846.1  neuroligin-2 precursor

    See identical proteins and their annotated locations for NP_065846.1

    Status: REVIEWED

    Source sequence(s)
    AA447769, AC113189, AF376802, AI613237, BM800364, DR763679, EL949788
    Consensus CDS
    CCDS11103.1
    UniProtKB/Swiss-Prot
    Q8NFZ4, Q9P2I1
    Related
    ENSP00000305288.2, ENST00000302926.7
    Conserved Domains (2) summary
    COG0657
    Location:170268
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:41601
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7404653..7419860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436464.1XP_047292420.1  neuroligin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2I1
  2. XM_047436463.1XP_047292419.1  neuroligin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2I1
  3. XM_047436465.1XP_047292421.1  neuroligin-2 isoform X2

  4. XM_047436462.1XP_047292418.1  neuroligin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9P2I1
    Related
    ENSP00000461168.1, ENST00000575301.5
  5. XM_017024897.2XP_016880386.1  neuroligin-2 isoform X3

    Conserved Domains (2) summary
    COG0657
    Location:189
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:1422
    COesterase; Carboxylesterase family

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_016107299.1 Reference GRCh38.p14 PATCHES

    Range
    28302..40317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7311889..7323908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)