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MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 [ Homo sapiens (human) ]

Gene ID: 57553, updated on 4-Jun-2020

Summary

Official Symbol
MICAL3provided by HGNC
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 3provided by HGNC
Primary source
HGNC:HGNC:24694
See related
Ensembl:ENSG00000243156 MIM:608882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MICAL-3
Expression
Ubiquitous expression in testis (RPKM 5.1), brain (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See MICAL3 in Genome Data Viewer
Location:
22q11.21
Exon count:
37
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (17787649..18024561, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18270415..18507325, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene nonconserved acetylation island sequence 74 enhancer Neighboring gene VISTA enhancer hs2543 Neighboring gene long intergenic non-protein coding RNA 528 Neighboring gene microRNA 648 Neighboring gene long intergenic non-protein coding RNA 1634 Neighboring gene RHEB pseudogene 3 Neighboring gene uncharacterized LOC105372853

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Genome-wide association study of antiphospholipid antibodies.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of microtubule associated monoxygenase, calponin and LIM domain containing 3 (MICAL3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37503, KIAA0819, MGC189703

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Flemming body IDA
Inferred from Direct Assay
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
[F-actin]-monooxygenase MICAL3
Names
[F-actin]-methionine sulfoxide oxidase MICAL3
flavoprotein oxidoreductase MICAL3
molecule interacting with CasL protein 3
protein MICAL-3
protein-methionine sulfoxide oxidase MICAL3
NP_001116203.1
NP_001129476.1
NP_056056.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122731.2NP_001116203.1  [F-actin]-monooxygenase MICAL3 isoform 3

    See identical proteins and their annotated locations for NP_001116203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the UTRs and coding region, including the lack of multiple 3' coding exons, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB037785, BC085009, BX647382, DA531335
    Consensus CDS
    CCDS46660.1
    UniProtKB/Swiss-Prot
    Q7RTP6
    Related
    ENSP00000383406.2, ENST00000400561.6
    Conserved Domains (4) summary
    cd09439
    Location:764818
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:524619
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    pfam13450
    Location:91119
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_001136004.3NP_001129476.1  [F-actin]-monooxygenase MICAL3 isoform 2

    See identical proteins and their annotated locations for NP_001129476.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, including the lack of multiple 3' coding exons, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC016026, BC157876, BU617485, DA531335, KC877929
    Consensus CDS
    CCDS46661.1
    UniProtKB/Swiss-Prot
    Q7RTP6
    Related
    ENSP00000462033.1, ENST00000585038.1
    Conserved Domains (4) summary
    cd09439
    Location:888942
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:524619
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    pfam13450
    Location:91119
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_015241.3NP_056056.2  [F-actin]-monooxygenase MICAL3 isoform 1

    See identical proteins and their annotated locations for NP_056056.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB020626, AC016026, AC016027, BC035213, CR456364, DA531335, DR731344
    Consensus CDS
    CCDS46659.1
    UniProtKB/Swiss-Prot
    Q7RTP6
    Related
    ENSP00000416015.2, ENST00000441493.7
    Conserved Domains (5) summary
    cd09439
    Location:764818
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:524619
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    pfam12130
    Location:18501971
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:91119
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    17787649..18024561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020793.1: Suppressed sequence

    Description
    NM_020793.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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