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TAOK1 TAO kinase 1 [ Homo sapiens (human) ]

Gene ID: 57551, updated on 5-Apr-2020

Summary

Official Symbol
TAOK1provided by HGNC
Official Full Name
TAO kinase 1provided by HGNC
Primary source
HGNC:HGNC:29259
See related
Ensembl:ENSG00000160551 MIM:610266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16
Expression
Ubiquitous expression in brain (RPKM 14.1), thyroid (RPKM 11.3) and 25 other tissues See more
Orthologs

Genomic context

See TAOK1 in Genome Data Viewer
Location:
17q11.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (29390925..29551904)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27717943..27878921)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, U4 small nuclear 34, pseudogene Neighboring gene microRNA 4523 Neighboring gene RNA, U6 small nuclear 711, pseudogene Neighboring gene RNA, U6 small nuclear 1034, pseudogene Neighboring gene abhydrolase domain containing 15 Neighboring gene tumor protein p53 inducible protein 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
NHGRI GWA Catalog
A genome-wide association study identifies three loci associated with mean platelet volume.
NHGRI GWA Catalog
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
NHGRI GWA Catalog
New gene functions in megakaryopoiesis and platelet formation.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TAO kinase 1 (TAOK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14314, KIAA1361

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
G2 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
microtubule cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
perinuclear region of cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase TAO1
Names
MARK Kinase
STE20-like kinase PSK2
kinase from chicken homolog B
microtubule affinity regulating kinase kinase
prostate-derived STE20-like kinase 2
prostate-derived sterile 20-like kinase 2
serine/threonine protein kinase TAO1 homolog
thousand and one amino acid protein 1
thousand and one amino acid protein kinase 1
NP_065842.1
NP_079418.1
XP_011523362.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020791.4NP_065842.1  serine/threonine-protein kinase TAO1 isoform 1

    See identical proteins and their annotated locations for NP_065842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068025, AC090698, BC133039, CK300429
    Consensus CDS
    CCDS32601.1
    UniProtKB/Swiss-Prot
    Q7L7X3
    UniProtKB/TrEMBL
    A0A024QZ70
    Related
    ENSP00000261716.3, ENST00000261716.7
    Conserved Domains (2) summary
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    cl25732
    Location:452876
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_025142.1NP_079418.1  serine/threonine-protein kinase TAO1 isoform 2

    See identical proteins and their annotated locations for NP_079418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC068025, AC090698, BC144067, CK300429
    Consensus CDS
    CCDS56024.1
    UniProtKB/Swiss-Prot
    Q7L7X3
    Related
    ENSP00000438819.1, ENST00000536202.1
    Conserved Domains (1) summary
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    29390925..29551904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525060.2XP_011523362.1  serine/threonine-protein kinase TAO1 isoform X1

    See identical proteins and their annotated locations for XP_011523362.1

    UniProtKB/Swiss-Prot
    Q7L7X3
    UniProtKB/TrEMBL
    A0A024QZ70
    Conserved Domains (2) summary
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    cl25732
    Location:452876
    SMC_N; RecF/RecN/SMC N terminal domain
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