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TAOK1 TAO kinase 1 [ Homo sapiens (human) ]

Gene ID: 57551, updated on 5-Sep-2021

Summary

Official Symbol
TAOK1provided by HGNC
Official Full Name
TAO kinase 1provided by HGNC
Primary source
HGNC:HGNC:29259
See related
Ensembl:ENSG00000160551 MIM:610266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16
Expression
Ubiquitous expression in brain (RPKM 14.1), thyroid (RPKM 11.3) and 25 other tissues See more
Orthologs
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Genomic context

See TAOK1 in Genome Data Viewer
Location:
17q11.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (29390363..29551903)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27717381..27878921)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 35 Neighboring gene RNA, U4 small nuclear 34, pseudogene Neighboring gene microRNA 4523 Neighboring gene RNA, U6 small nuclear 711, pseudogene Neighboring gene RNA, U6 small nuclear 1034, pseudogene Neighboring gene abhydrolase domain containing 15 Neighboring gene tumor protein p53 inducible protein 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
GeneReviews: Not available
A genome-wide association study identifies three loci associated with mean platelet volume.
GeneReviews: Not available
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
GeneReviews: Not available
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.
GeneReviews: Not available
New gene functions in megakaryopoiesis and platelet formation.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of TAO kinase 1 (TAOK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14314, KIAA1361

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in execution phase of apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in microtubule cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in perinuclear region of cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase TAO1
Names
MARK Kinase
STE20-like kinase PSK2
kinase from chicken homolog B
microtubule affinity regulating kinase kinase
prostate-derived STE20-like kinase 2
prostate-derived sterile 20-like kinase 2
serine/threonine protein kinase TAO1 homolog
thousand and one amino acid protein 1
thousand and one amino acid protein kinase 1
NP_065842.1
NP_079418.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020791.4NP_065842.1  serine/threonine-protein kinase TAO1 isoform 1

    See identical proteins and their annotated locations for NP_065842.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC068025, AC090698, BC133039, CK300429
    Consensus CDS
    CCDS32601.1
    UniProtKB/Swiss-Prot
    Q7L7X3
    UniProtKB/TrEMBL
    A0A024QZ70
    Related
    ENSP00000261716.3, ENST00000261716.8
    Conserved Domains (2) summary
    COG0419
    Location:442877
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
  2. NM_025142.1NP_079418.1  serine/threonine-protein kinase TAO1 isoform 2

    See identical proteins and their annotated locations for NP_079418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC068025, AC090698, BC144067, CK300429
    Consensus CDS
    CCDS56024.1
    UniProtKB/Swiss-Prot
    Q7L7X3
    Related
    ENSP00000438819.1, ENST00000536202.1
    Conserved Domains (1) summary
    cd06635
    Location:2318
    STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    29390363..29551903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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