U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DISP3 dispatched RND transporter family member 3 [ Homo sapiens (human) ]

Gene ID: 57540, updated on 22-Sep-2022

Summary

Official Symbol
DISP3provided by HGNC
Official Full Name
dispatched RND transporter family member 3provided by HGNC
Primary source
HGNC:HGNC:29251
See related
Ensembl:ENSG00000204624 MIM:611251; AllianceGenome:HGNC:29251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTCHD2
Summary
Involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 1.6), testis (RPKM 1.4) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DISP3 in Genome Data Viewer
Location:
1p36.22
Exon count:
24
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11479155..11537551)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11022097..11081879)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11539212..11597608)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903841 Neighboring gene MT-CYB pseudogene 45 Neighboring gene uncharacterized LOC124903842 Neighboring gene Sharpr-MPRA regulatory region 3841 Neighboring gene long intergenic non-protein coding RNA 1647

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
protein dispatched homolog 3
Names
dispatched 3
dispatched homolog 3
patched domain containing 2
patched domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020780.2NP_065831.1  protein dispatched homolog 3

    See identical proteins and their annotated locations for NP_065831.1

    Status: VALIDATED

    Source sequence(s)
    AB037758, AL117236, AL590989, BU733859
    Consensus CDS
    CCDS41247.1
    UniProtKB/Swiss-Prot
    Q9P2K9, Q9UJD6
    Related
    ENSP00000294484.6, ENST00000294484.7
    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11479155..11537551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426135.1XP_047282091.1  protein dispatched homolog 3 isoform X2

  2. XM_011541830.3XP_011540132.1  protein dispatched homolog 3 isoform X4

    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family
  3. XM_011541831.3XP_011540133.1  protein dispatched homolog 3 isoform X5

    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family
  4. XM_011541832.2XP_011540134.1  protein dispatched homolog 3 isoform X6

    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family
  5. XM_011541833.2XP_011540135.1  protein dispatched homolog 3 isoform X7

    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family
  6. XM_047426138.1XP_047282094.1  protein dispatched homolog 3 isoform X8

  7. XM_011541835.2XP_011540137.1  protein dispatched homolog 3 isoform X9

    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family
  8. XM_011541828.4XP_011540130.1  protein dispatched homolog 3 isoform X1

    See identical proteins and their annotated locations for XP_011540130.1

    UniProtKB/Swiss-Prot
    Q9P2K9, Q9UJD6
    Conserved Domains (3) summary
    pfam12235
    Location:148255
    FXMRP1_C_core; Fragile X-related 1 protein core C terminal
    cl01888
    Location:102170
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21543
    Location:485615
    MMPL; MMPL family
  9. XM_011541829.2XP_011540131.1  protein dispatched homolog 3 isoform X3

    Conserved Domains (1) summary
    cl21543
    Location:114244
    MMPL; MMPL family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    11022097..11081879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)