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NUFIP2 nuclear FMR1 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 57532, updated on 18-Jan-2026
Official Symbol
NUFIP2provided by HGNC
Official Full Name
nuclear FMR1 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:17634
See related
Ensembl:ENSG00000108256 MIM:609356; AllianceGenome:HGNC:17634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG1; NUFP2; 82-FIP; FIP-82; 182-FIP
Summary
Enables RNA binding activity. Located in several cellular components, including cytoplasmic stress granule; nuclear body; and ribosome. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 15.1), placenta (RPKM 12.6) and 25 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See NUFIP2 in Genome Data Viewer
Location:
17q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29255839..29294148, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30198607..30236882, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27582857..27621166, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27538979-27539479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11969 Neighboring gene twinfilin 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8369 Neighboring gene crystallin beta A1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27616618-27617118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27617119-27617619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27620471-27621231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11971 Neighboring gene ribosomal protein L35a pseudogene 35 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11972 Neighboring gene Sharpr-MPRA regulatory region 6423 Neighboring gene RNA, U4 small nuclear 34, pseudogene

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction. Ramos A, et al. Structure, 2006 Jan. PMID 16407062
  2. FMRP phosphorylation modulates neuronal translation through YTHDF1. Zou Z, et al. Mol Cell, 2023 Dec 7. PMID 37949069, Free PMC Article
  3. Novel FMRP interaction networks linked to cellular stress. Taha MS, et al. FEBS J, 2021 Feb. PMID 32525608
  4. 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization. Bardoni B, et al. Hum Mol Genet, 2003 Jul 15. PMID 12837692
  5. Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma. Zhang L, et al. J Hepatol, 2024 Jan. PMID 37838036

See all (169) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FMRP phosphorylation modulates neuronal translation through YTHDF1.
    Title: FMRP phosphorylation modulates neuronal translation through YTHDF1.
  2. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
    Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
  3. identification and characterization of FIP-82, a novel FMRP-interacting protein associated to polyribosomes as a component of mRNP complexes containing FMRP
    Title: 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10976, KIAA1321, MGC117262

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
FMR1-interacting protein NUFIP2
Names
82 kDa FMRP-interacting protein
82-kD FMRP Interacting Protein
FMRP-interacting protein 2
NUFIP2, FMR1 interacting protein 2
cell proliferation-inducing gene 1 protein
proliferation-inducing gene 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020772.3 → NP_065823.1  FMR1-interacting protein NUFIP2

    See identical proteins and their annotated locations for NP_065823.1

    Status: VALIDATED

    Source sequence(s)
    AB037742, AC005412, AK293075, BM969349
    Consensus CDS
    CCDS32600.1
    UniProtKB/Swiss-Prot
    A1L3A6, A1L3A7, Q7Z417, Q9P2M5
    Related
    ENSP00000225388.3, ENST00000225388.9
    Conserved Domains (1) summary
    pfam15293
    Location:89 → 688
    NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    29255839..29294148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024896.3 → XP_016880385.1  FMR1-interacting protein NUFIP2 isoform X1

    Conserved Domains (1) summary
    pfam15293
    Location:1 → 529
    NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    30198607..30236882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316746.1 → XP_054172721.1  FMR1-interacting protein NUFIP2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z417.1 GenPept UniProtKB/Swiss-Prot:Q7Z417

Gene LinkOut

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