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CGN cingulin [ Homo sapiens (human) ]

Gene ID: 57530, updated on 4-Dec-2022

Summary

Official Symbol
CGNprovided by HGNC
Official Full Name
cingulinprovided by HGNC
Primary source
HGNC:HGNC:17429
See related
Ensembl:ENSG00000143375 MIM:609473; AllianceGenome:HGNC:17429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables cadherin binding activity. Predicted to act upstream of or within bicellular tight junction assembly; epithelial cell morphogenesis; and microtubule cytoskeleton organization. Located in bicellular tight junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine (RPKM 30.7), duodenum (RPKM 28.7) and 15 other tissues See more
Orthologs
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Genomic context

See CGN in Genome Data Viewer
Location:
1q21.3
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151510170..151538692)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150635081..150662396)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151483863..151511168)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene pogo transposable element derived with ZNF domain Neighboring gene Sharpr-MPRA regulatory region 7521 Neighboring gene RNY4 pseudogene 25 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene tuftelin 1 Neighboring gene microRNA 554 Neighboring gene ribosomal protein S10 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39281, KIAA1319, DKFZp779N1112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cadherin binding HDA PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction NAS
Non-traceable Author Statement
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cell junction TAS
Traceable Author Statement
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020770.3NP_065821.1  cingulin

    See identical proteins and their annotated locations for NP_065821.1

    Status: VALIDATED

    Source sequence(s)
    AF263462, AL365436, BC146657, BC152445, BP331021, CN359389
    Consensus CDS
    CCDS999.1
    UniProtKB/Swiss-Prot
    Q9NR25, Q9P2M7
    Related
    ENSP00000271636.7, ENST00000271636.12
    Conserved Domains (1) summary
    cl25732
    Location:3681152
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    151510170..151538692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245365.6XP_005245422.1  cingulin isoform X1

    See identical proteins and their annotated locations for XP_005245422.1

    UniProtKB/Swiss-Prot
    Q9NR25, Q9P2M7
    Conserved Domains (1) summary
    cl25732
    Location:3681152
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. XR_921902.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    150635081..150662396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)