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KCTD16 potassium channel tetramerization domain containing 16 [ Homo sapiens (human) ]

Gene ID: 57528, updated on 11-Jun-2021

Summary

Official Symbol
KCTD16provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 16provided by HGNC
Primary source
HGNC:HGNC:29244
See related
Ensembl:ENSG00000183775 MIM:613423
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 4.6), lung (RPKM 0.4) and 3 other tissues See more
Orthologs
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Genomic context

See KCTD16 in Genome Data Viewer
Location:
5q31.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (144170723..144485686)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (143550437..143865249)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 87, pseudogene Neighboring gene Yip1 domain family member 5 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 5 Neighboring gene 60S ribosomal protein L9 pseudogene Neighboring gene RN7SK pseudogene 246

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1317, MGC138167, DKFZp781A1155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD16
Names
potassium channel tetramerisation domain containing 16
potassium channel tetramerization domain-containing protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370486.1NP_001357415.1  BTB/POZ domain-containing protein KCTD16

    Status: VALIDATED

    Source sequence(s)
    AC008383, AC008716
    Related
    ENSP00000426548.1, ENST00000507359.3
    Conserved Domains (2) summary
    cd18398
    Location:23125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16
  2. NM_001370487.1NP_001357416.1  BTB/POZ domain-containing protein KCTD16

    Status: VALIDATED

    Source sequence(s)
    AC008383, AC008716
    Conserved Domains (2) summary
    cd18398
    Location:23125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16
  3. NM_020768.4NP_065819.1  BTB/POZ domain-containing protein KCTD16

    See identical proteins and their annotated locations for NP_065819.1

    Status: VALIDATED

    Source sequence(s)
    AC008716, AK292477
    Consensus CDS
    CCDS34260.1
    UniProtKB/Swiss-Prot
    Q68DU8
    UniProtKB/TrEMBL
    A8K8W2
    Related
    ENSP00000424151.1, ENST00000512467.6
    Conserved Domains (2) summary
    cd18398
    Location:23125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    144170723..144485686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537671.2XP_011535973.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    See identical proteins and their annotated locations for XP_011535973.1

    UniProtKB/Swiss-Prot
    Q68DU8
    Conserved Domains (2) summary
    cd18398
    Location:23125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16
  2. XM_011537673.2XP_011535975.1  BTB/POZ domain-containing protein KCTD16 isoform X3

    Conserved Domains (2) summary
    smart00225
    Location:27121
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:27118
    BTB; BTB/POZ domain
  3. XM_011537672.2XP_011535974.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    Conserved Domains (2) summary
    smart00225
    Location:27121
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:27118
    BTB; BTB/POZ domain
  4. XM_005268493.2XP_005268550.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    See identical proteins and their annotated locations for XP_005268550.1

    UniProtKB/Swiss-Prot
    Q68DU8
    Conserved Domains (2) summary
    cd18398
    Location:23125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16
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