NYNRIN NYN domain and retroviral integrase containing [Homo sapiens (human)] - Gene

Summary

Official Symbol: NYNRINprovided by HGNC
Official Full Name: NYN domain and retroviral integrase containingprovided by HGNC
Primary source: HGNC:HGNC:20165
See related: Ensembl:ENSG00000205978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CGIN1; KIAA1305
Expression: Ubiquitous expression in ovary (RPKM 19.4), endometrium (RPKM 6.6) and 22 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 14q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	14	NC_000014.9 (24399003..24419283)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (24867992..24888494)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Discovery and refinement of loci associated with lipid levels. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH66363 (e-PCR)
- UniSTS:79381

SHGC-141849 (e-PCR)
- UniSTS:171113

IB2324 (e-PCR)
- UniSTS:24052

Homology

Homologs of the NYNRIN gene: The NYNRIN gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 139 organisms have orthologs with human gene NYNRIN
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
molecular_function	ND No biological Data available more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA integration	IEA Inferred from Electronic Annotation more info
biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
integral component of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein NYNRIN

Names: Cousin of GIN1; NYN domain and retroviral integrase catalytic domain-containing protein; protein cousin of GIN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025081.3 → NP_079357.2 protein NYNRIN

See identical proteins and their annotated locations for NP_079357.2

Status: VALIDATED

Source sequence(s)

AB037726, AL132800, BC065283

Consensus CDS

CCDS45090.1

UniProtKB/Swiss-Prot

Q9P2P1

Related

ENSP00000371994.3, ENST00000382554.4

Conserved Domains (2) summary

pfam11977
Location:791 → 942

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

cl14782
Location:1161 → 1264

RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p13 Primary Assembly

Range

24399003..24419283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537016.2 → XP_011535318.1 protein NYNRIN isoform X1

Conserved Domains (2) summary

cl14782
Location:281 → 384

RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8

cl20439
Location:2 → 62

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain