NYNRIN NYN domain and retroviral integrase containing [Homo sapiens (human)] - Gene

Summary

Official Symbol: NYNRINprovided by HGNC
Official Full Name: NYN domain and retroviral integrase containingprovided by HGNC
Primary source: HGNC:HGNC:20165
See related: Ensembl:ENSG00000205978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CGIN1; KIAA1305
Expression: Ubiquitous expression in ovary (RPKM 19.4), endometrium (RPKM 6.6) and 22 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14q12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
109.20211119	current	GRCh38.p13 (GCF_000001405.39)	14	NC_000014.9 (24399003..24419283)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (24868209..24888489)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Biological, clinical and population relevance of 95 loci for blood lipids. GeneReviews: Not available
Discovery and refinement of loci associated with lipid levels. GeneReviews: Not available

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH66363 (e-PCR)
- UniSTS:79381

SHGC-141849 (e-PCR)
- UniSTS:171113

IB2324 (e-PCR)
- UniSTS:24052

Homology

Homologs of the NYNRIN gene: The NYNRIN gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 168 organisms have orthologs with human gene NYNRIN
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables endoribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA integration	IEA Inferred from Electronic Annotation more info
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in integral component of membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: protein NYNRIN

Names: Cousin of GIN1; NYN domain and retroviral integrase catalytic domain-containing protein; protein cousin of GIN1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025081.3 → NP_079357.2 protein NYNRIN

See identical proteins and their annotated locations for NP_079357.2

Status: VALIDATED

Source sequence(s)

AB037726, AL132800, BC065283

Consensus CDS

CCDS45090.1

UniProtKB/Swiss-Prot

Q9P2P1

Related

ENSP00000371994.3, ENST00000382554.4

Conserved Domains (2) summary

pfam11977
Location:791 → 942

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

cl14782
Location:1161 → 1264

RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p13 Primary Assembly

Range

24399003..24419283

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011537016.2 → XP_011535318.1 protein NYNRIN isoform X1

Conserved Domains (2) summary

cl14782
Location:281 → 384

RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8

cl20439
Location:2 → 62

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain