Format

Send to:

Choose Destination

XPO5 exportin 5 [ Homo sapiens (human) ]

Gene ID: 57510, updated on 7-Aug-2021

Summary

Official Symbol
XPO5provided by HGNC
Official Full Name
exportin 5provided by HGNC
Primary source
HGNC:HGNC:17675
See related
Ensembl:ENSG00000124571 MIM:607845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp5
Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 18.4), thyroid (RPKM 10.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See XPO5 in Genome Data Viewer
Location:
6p21.1
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43522334..43576038, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43490072..43543775, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 73 Neighboring gene RNA polymerase I and III subunit C Neighboring gene Yip1 domain family member 3 Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene DNA polymerase eta Neighboring gene MAD2L1 binding protein Neighboring gene GTP binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 5 (XPO5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14239, FLJ32057, FLJ45606, KIAA1291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RISC complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding TAS
Traceable Author Statement
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear export signal receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pre-miRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA nuclear export complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA nuclear export complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exportin-5
Names
ran-binding protein 21

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051658.1 RefSeqGene

    Range
    5038..58742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020750.3NP_065801.1  exportin-5

    See identical proteins and their annotated locations for NP_065801.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AB033117, AF298880, BF108994, DB068849
    Consensus CDS
    CCDS47430.1
    UniProtKB/Swiss-Prot
    Q9HAV4
    Related
    ENSP00000265351.7, ENST00000265351.12
    Conserved Domains (2) summary
    COG5101
    Location:64353
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
    pfam08389
    Location:109248
    Xpo1; Exportin 1-like protein

RNA

  1. NR_144392.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL355802, KF458158, KF510953

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43522334..43576038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center