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XPO5 exportin 5 [ Homo sapiens (human) ]

Gene ID: 57510, updated on 21-Apr-2019

Summary

Official Symbol
XPO5provided by HGNC
Official Full Name
exportin 5provided by HGNC
Primary source
HGNC:HGNC:17675
See related
Ensembl:ENSG00000124571 MIM:607845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp5
Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Expression
Broad expression in testis (RPKM 18.4), thyroid (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See XPO5 in Genome Data Viewer
Location:
6p21.1
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (43522330..43576075, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43490068..43543812, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 73 Neighboring gene Yip1 domain family member 3 Neighboring gene RNA polymerase I and III subunit C Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene DNA polymerase eta Neighboring gene GTP binding protein 2 Neighboring gene MAD2L1 binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 5 (XPO5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Gene Silencing by RNA, organism-specific biosystem (from REACTOME)
    Gene Silencing by RNA, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
    MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
  • RNA interference, organism-specific biosystem (from WikiPathways)
    RNA interference, organism-specific biosystemThe process of RNA-interference in eukaryotic cells. Long precursor microRNA (miRNA), called pri-miRNA, is cleaved by RNase III endonuclease (Drosha) into pieces of approximately 70 nucleotides each ...
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • miRNA Biogenesis, organism-specific biosystem (from WikiPathways)
    miRNA Biogenesis, organism-specific biosystemmicroRNA biogenesis + an example of a miRBase entry. As an example immature hsa-mir-146a is shown

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14239, FLJ32057, FLJ45606, KIAA1291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding TAS
Traceable Author Statement
more info
 
Ran GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear export signal receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to pre-miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
miRNA metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pre-miRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-miRNA export from nucleus NAS
Non-traceable Author Statement
more info
PubMed 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
RNA nuclear export complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
micro-ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear RNA export factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exportin-5
Names
ran-binding protein 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051658.1 RefSeqGene

    Range
    5001..58746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020750.3NP_065801.1  exportin-5

    See identical proteins and their annotated locations for NP_065801.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AB033117, AF298880, BF108994, DB068849
    Consensus CDS
    CCDS47430.1
    UniProtKB/Swiss-Prot
    Q9HAV4
    Related
    ENSP00000265351.7, ENST00000265351.12
    Conserved Domains (2) summary
    smart00913
    Location:33100
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:109248
    Xpo1; Exportin 1-like protein

RNA

  1. NR_144392.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL355802, KF458158, KF510953

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    43522330..43576075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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